Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 6/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.37 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.37 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL648135 | 0.96 | CRHR1 (0.44) | AGTR1DRD2TBXA2RADORA2AADORA2B | |
| SCHEMBL650306 | 0.93 | CRHR1 (0.38) | AGTR1DRD2TBXA2RADORA2AADORA2B | |
| SCHEMBL651310 | 0.93 | NR1H4 (0.39) | AGTR1DRD2TBXA2RADORA2AADORA2B | |
| SCHEMBL652369 | 0.92 | CRHR1 (0.40) | AGTR1DRD2TBXA2RADORA2AADORA2B | |
| SCHEMBL648054 | 0.91 | NR1H2 (0.39) | AGTR1CRHR1TLR7 | |
| SCHEMBL651025 | 0.90 | C5AR1 (0.48) | AGTR1MAPTALDH1A1TLR7C5AR1 | |
| SCHEMBL652145 | 0.90 | TLR7 (0.38) | AGTR1CRHR1ALDH1A1TLR7C5AR1 | |
| SCHEMBL649436 | 0.90 | C5AR1 (0.54) | MAPTKDM4EALDH1A1C5AR1TSHR | |
| SCHEMBL650668 | 0.90 | AGTR1 (0.38) | AGTR1DRD2TBXA2RADORA2AADORA2B | |
| SCHEMBL650362 | 0.89 | TLR7 (0.37) | AGTR1CRHR1MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |