Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.37 |
| ▸ | CETP | P11597 | 5/20 | 0.37 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL652145 | 0.94 | TLR7 (0.38) | TLR7CRHR1CETPC5AR1NR1H2 | |
| SCHEMBL652150 | 0.94 | CRHR1 (0.38) | CRHR1CETPC5AR1 | |
| SCHEMBL651143 | 0.92 | CRHR1 (0.37) | TLR7CRHR1CETPC5AR1 | |
| SCHEMBL651113 | 0.91 | CRHR1 (0.42) | CRHR1CETPC5AR1 | |
| SCHEMBL648054 | 0.91 | NR1H2 (0.39) | TLR7CRHR1NR1H2AGTR1 | |
| SCHEMBL1913086 | 0.89 | AGTR1 (0.41) | TLR7CRHR1C5AR1AGTR1KDM4E | |
| SCHEMBL650193 | 0.88 | CRHR1 (0.40) | CRHR1CETPC5AR1 | |
| SCHEMBL651310 | 0.88 | NR1H4 (0.39) | CRHR1AGTR1ALDH1A1 | |
| SCHEMBL651001 | 0.88 | CRHR1 (0.38) | CRHR1C5AR1 | |
| SCHEMBL651662 | 0.86 | CRHR1 (0.37) | CRHR1CETPC5AR1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |