Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.33 |
| ▸ | CASR | P41180 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL652707 | 0.95 | USP2 (0.39) | USP2SMN1; SMN2CRHR1HPGDALDH1A1 | |
| SCHEMBL1918604 | 0.92 | USP2 (0.38) | USP2SMN1; SMN2CRHR1CASRHPGD | |
| SCHEMBL651107 | 0.88 | TSHR (0.38) | USP2SMN1; SMN2HPGDALDH1A1KDM4E | |
| SCHEMBL648275 | 0.84 | TLR7 (0.34) | USP2ALDH1A1HSD17B10 | |
| SCHEMBL650433 | 0.78 | CRHR1 (0.36) | USP2CRHR1CASRHPGDALDH1A1 | |
| SCHEMBL649555 | 0.76 | SMN1; SMN2 (0.35) | USP2SMN1; SMN2CRHR1CASRALDH1A1 | |
| SCHEMBL5929010 | 0.74 | ALDH1A1 (0.35) | USP2CASRHPGDALDH1A1HSD17B10 | |
| SCHEMBL649322 | 0.73 | SQLE (0.35) | — | |
| SCHEMBL1912823 | 0.71 | ALDH1A1 (0.47) | USP2SMN1; SMN2CASRHPGDALDH1A1 | |
| SCHEMBL648638 | 0.71 | KMT2A (0.32) | CRHR1MEN1KMT2APTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |