Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1913115 | 0.92 | USP2 (0.38) | USP2SMN1; SMN2HPGDCRHR1ALDH1A1 | |
| SCHEMBL652707 | 0.87 | USP2 (0.39) | USP2SMN1; SMN2HPGDCRHR1ALDH1A1 | |
| SCHEMBL651107 | 0.79 | TSHR (0.38) | USP2SMN1; SMN2HPGDALDH1A1KDM4E | |
| SCHEMBL648275 | 0.77 | TLR7 (0.34) | USP2ALDH1A1CYP3A4CYP1A2TSHR | |
| SCHEMBL648645 | 0.70 | PPARG (0.35) | HPGDTSHRMEN1KMT2AMAPT | |
| SCHEMBL650433 | 0.68 | CRHR1 (0.36) | USP2HPGDCRHR1ALDH1A1MAPK1 | |
| SCHEMBL649555 | 0.68 | SMN1; SMN2 (0.35) | USP2SMN1; SMN2CRHR1ALDH1A1KDM4E | |
| SCHEMBL649322 | 0.64 | SQLE (0.35) | TLR7 | |
| SCHEMBL5929010 | 0.64 | ALDH1A1 (0.35) | USP2HPGDALDH1A1MAPK1CYP3A4 | |
| SCHEMBL29377889 | 0.63 | TSHR (0.50) | ALDH1A1KDM4EMAPK1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |