Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | CD38 | P28907 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1609860 | 0.81 | CD38 (0.47) | ROCK2ROCK1CD38SMYD3 | |
| SCHEMBL4886377 | 0.78 | SMN1; SMN2 (0.51) | ROCK2 | |
| SCHEMBL19132785 | 0.78 | RORC (0.48) | RORCHPGDSAR | |
| SCHEMBL19132740 | 0.76 | ROCK2 (0.40) | RORCROCK2ROCK1HPGDSCD38 | |
| SCHEMBL20387472 | 0.76 | SMYD3 (0.54) | HPGDSSMYD3 | |
| SCHEMBL11898543 | 0.75 | HPGDS (0.48) | ROCK2ROCK1HPGDSKDM1A | |
| SCHEMBL19132783 | 0.73 | RORC (0.51) | RORCHPGDSSMYD3 | |
| SCHEMBL19139056 | 0.71 | RORC (0.50) | RORC | |
| SCHEMBL19132827 | 0.70 | TSHR (0.45) | RORC | |
| SCHEMBL24767228 | 0.70 | EPHX2 (0.40) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708253-B2 | Cyclohexyl sulfone RORγ modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-07-18 | — | — | US | disclosed |