Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 2/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.30 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.30 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
| ▸ | GRK6 | P43250 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18672324 | 0.85 | NOS1 (0.34) | KMOALDH1A1 | |
| SCHEMBL27407274 | 0.75 | SMN1; SMN2 (0.34) | GRM5ALDH1A1 | |
| SCHEMBL22639190 | 0.75 | CYP2D6 (0.34) | KCNH2L3MBTL1 | |
| SCHEMBL12120627 | 0.74 | SYK (0.40) | KCNH2 | |
| SCHEMBL20756493 | 0.73 | NOS1 (0.36) | ALDH1A1RXRAGRIN1GRIN2B | |
| SCHEMBL22808233 | 0.73 | L3MBTL1 (0.48) | APLNRKMOMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL24805770 | 0.72 | ADRB1 (0.41) | — | |
| SCHEMBL2609315 | 0.72 | PTK2 (0.38) | APLNRMAPK1L3MBTL1S1PR3S1PR2 | |
| SCHEMBL26532692 | 0.71 | ADRB1 (0.43) | GRM5TSHR | |
| SCHEMBL21245999 | 0.70 | HCRTR1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708331-B2 | Metabotrophic glutamate receptor 5 modulators and methods of use thereof | SUNOVION PHARMACEUTICALS INC. (US) | 2017-07-18 | — | — | US | disclosed |