Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALAD | P13716 | 1/20 | 0.42 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | ATM | Q13315 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18858485 | 0.82 | ALAD (0.47) | ALADSREBF2ALDH1A1MAPK1MAPT | |
| SCHEMBL19134548 | 0.80 | CES2 (0.31) | ALDH1A1LMNA | |
| SCHEMBL19134522 | 0.70 | ESR1 (0.33) | — | |
| SCHEMBL18869442 | 0.69 | HDAC6 (0.39) | SREBF2ALDH1A1MAPK1MAPTATM | |
| SCHEMBL18869535 | 0.69 | ALAD (0.52) | ALADALDH1A1MAPK1MAPTL3MBTL1 | |
| SCHEMBL14817169 | 0.66 | TSHR (0.38) | SREBF2ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL27794744 | 0.66 | ALAD (0.66) | ALADALDH1A1MAPK1MAPTL3MBTL1 | |
| SCHEMBL12982919 | 0.65 | ESR1 (0.45) | ALDH1A1MAPK1KDM4E | |
| SCHEMBL12465845 | 0.65 | ALAD (0.52) | ALADALDH1A1MAPK1MAPTKDM4E | |
| SCHEMBL12529448 | 0.65 | ALAD (0.47) | ALADALDH1A1MAPTL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708323-B2 | Tricyclic compounds as alpha-7 nicotinic acetylcholine receptor ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-07-18 | — | — | US | disclosed |