Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ACP3 | P15309 | 2/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL27653719 | 0.88 | ALDH1A1 (0.60) | ALDH1A1CYP1A2MMP3BCL2L1ESR2 | |
| Biphenyl SCHEMBL28046879 | 0.88 | ALDH1A1 (0.60) | ALDH1A1CYP1A2MMP3BCL2L1CA2 | |
| Biphenyl SCHEMBL1913481 | 0.82 | ACP3 (0.54) | ALDH1A1CYP1A2MMP3BCL2L1ACP3 | |
| Biphenyl SCHEMBL17182196 | 0.82 | ACP3 (0.54) | ALDH1A1CYP1A2MMP3BCL2L1ACP3 | |
| Biphenyl SCHEMBL11506188 | 0.82 | ACP3 (0.54) | ALDH1A1CYP1A2MMP3BCL2L1ACP3 | |
| Biphenyl SCHEMBL27595243 | 0.82 | ALDH1A1 (0.53) | ALDH1A1CYP1A2MMP3BCL2L1ESR2 | |
| Biphenyl SCHEMBL1913599 | 0.78 | ACP3 (0.50) | ALDH1A1CYP1A2MMP3BCL2L1ACP3 | |
| Biphenyl SCHEMBL27755857 | 0.77 | ALDH1A1 (0.75) | ALDH1A1CYP1A2MMP3BCL2L1ESR2 | |
| Biphenyl SCHEMBL28098924 | 0.77 | ALDH1A1 (0.90) | ALDH1A1CYP1A2MMP3BCL2L1CA2 | |
| Biphenyl SCHEMBL263925 | 0.75 | ALDH1A1 (0.60) | ALDH1A1MMP3BCL2L1ACP3PTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883765-B2 | Anti-cytomegalovirus activity of artemisinin-derived dimers | THE JOHN HOPKINS UNIVERSITY (US) | 2014-11-11 | — | — | US | disclosed |
| US-20130109654-A1 | ANTI-CYTOMEGALOVIRUS ACTIVITY OF ARTEMISININ-DERIVED DIMERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2013-05-02 | — | — | US | disclosed |
| WO-2011071981-A2 | ANTI-CYTOMEGALOVIRUS ACTIVITY OF ARTEMISININ-DERIVED DIMERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109654-A1 | ANTI-CYTOMEGALOVIRUS ACTIVITY OF ARTEMISININ-DERIVED DIMERS | EIF2AK2, MAVS, PARP16 | ALDH1A1 800/4885CYP1A2 1762/4885MMP3 3280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.