Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | FADS1 | O60427 | 2/20 | 0.45 |
| ▸ | RRM1 | P23921 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1913833 | 0.77 | KDM4E (0.52) | ALDH1A1KDM4ERAB9ANPC1RRM1 | |
| SCHEMBL14727423 | 0.75 | ALDH1A1 (0.73) | ALDH1A1KDM4ERAB9ANPC1HPGD | |
| SCHEMBL1638617 | 0.74 | KMT2A (0.59) | ALDH1A1KDM4ERAB9ANPC1FADS1 | |
| SCHEMBL12766742 | 0.74 | KMT2A (0.59) | ALDH1A1KDM4ERAB9ANPC1FADS1 | |
| SCHEMBL1638615 | 0.74 | KMT2A (0.59) | ALDH1A1KDM4ERAB9ANPC1FADS1 | |
| SCHEMBL17241597 | 0.72 | MAPT (0.72) | ALDH1A1KDM4ERAB9ANPC1HPGD | |
| SCHEMBL11302560 | 0.70 | KMT2A (0.56) | ALDH1A1KDM4ERAB9ANPC1MAPT | |
| SCHEMBL13834567 | 0.70 | RAB9A (0.72) | ALDH1A1KDM4ERAB9ANPC1HPGD | |
| SCHEMBL13834568 | 0.70 | RAB9A (0.72) | ALDH1A1KDM4ERAB9ANPC1HPGD | |
| SCHEMBL1961988 | 0.69 | FADS1 (0.73) | ALDH1A1KDM4ERAB9ANPC1FADS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3151818-A1 | COMPOSITIONS AND METHODS OF TREATING DIABETIC RETINOPATHY | Case Western Reserve University (US) | 2017-04-12 | — | — | EP | disclosed |
| WO-2015187942-A1 | COMPOSITIONS AND METHODS OF TREATING DIABETIC RETINOPATHY | CASE WESTERN RESERVE UNIVERSITY (US) | 2015-12-10 | — | — | WO | disclosed |
| WO-2013063269-A2 | COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS | CASE WESTERN RESERVE UNIVERSITY (US) | 2013-05-02 | — | — | WO | disclosed |
| EP-2509596-A2 | COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS | Case Western Reserve University (US) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011071995-A2 | COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS | CASE WESTERN RESERVE UNIVERSITY (US) | 2011-06-16 | — | — | WO | disclosed |