Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | LMNA | P02545 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5458262 | 0.71 | NUDT1 (0.50) | NUDT1SMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL13828994 | 0.68 | NUDT1 (0.46) | NUDT1SMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL19155514 | 0.67 | SMN1; SMN2 (0.38) | NUDT1SMN1; SMN2TSHRALDH1A1LMNA | |
| SCHEMBL25229551 | 0.66 | CYP3A4 (0.45) | SMN1; SMN2TSHRHSD17B10ALDH1A1HPGD | |
| SCHEMBL7930954 | 0.65 | SMN1; SMN2 (0.49) | SMN1; SMN2HSD17B10ALDH1A1LMNAMAPT | |
| SCHEMBL25737360 | 0.65 | NUDT1 (0.38) | NUDT1SMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL24710969 | 0.65 | NUDT1 (0.43) | NUDT1SMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL4973147 | 0.64 | SMN1; SMN2 (0.48) | SMN1; SMN2KMT2AHSD17B10ALDH1A1LMNA | |
| SCHEMBL2815267 | 0.64 | MAPK1 (0.51) | NUDT1SMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL13828583 | 0.64 | SMN1; SMN2 (0.48) | NUDT1SMN1; SMN2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046799-B1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GENENTECH INC (US) | 2017-07-19 | — | — | EP | disclosed |