Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5445110 | 0.85 | NUDT1 (0.51) | NUDT1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL5450737 | 0.81 | ALDH1A1 (0.47) | NUDT1KDM4ESMN1; SMN2TSHRHSD17B10 | |
| SCHEMBL5457164 | 0.80 | NUDT1 (0.46) | NUDT1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL5452783 | 0.74 | NUDT1 (0.51) | NUDT1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL13828586 | 0.73 | SMN1; SMN2 (0.42) | NUDT1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL898825 | 0.72 | POLB (0.47) | KDM4EMEN1KMT2APOLBPIK3CA | |
| SCHEMBL12462778 | 0.72 | MTOR (0.56) | KDM4ESMN1; SMN2POLBALDH1A1L3MBTL1 | |
| SCHEMBL19142137 | 0.71 | NUDT1 (0.45) | NUDT1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL5453324 | 0.71 | KDM4E (0.52) | NUDT1KDM4ESMN1; SMN2TSHRHSD17B10 | |
| SCHEMBL2153355 | 0.71 | MTOR (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070259849-A1 | Azine-Carboxamides as Anti-Cancer Agents | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259849-A1 | Azine-Carboxamides as Anti-Cancer Agents | ARAF, BRAF, RAF1 | NUDT1 779/4885KDM4E 521/4885SMN1; SMN2 3928/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.