Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.59 |
| ▸ | CCR1 | P32246 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | CCR5 | P51681 | 1/20 | 0.58 |
| ▸ | PSMD14 | O00487 | 3/20 | 0.52 |
| ▸ | COPS5 | Q92905 | 3/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2115749 | 0.77 | CCR1 (0.64) | METAP2CCR1RAB9ACCR5PARP1 | |
| SCHEMBL806441 | 0.77 | CCR1 (0.64) | METAP2CCR1RAB9ACCR5PARP1 | |
| Neocuproine SCHEMBL18047476 | 0.76 | CCR1 (0.88) | METAP2CCR1RAB9ACCR5PARP1 | |
| SCHEMBL27782197 | 0.76 | CCR1 (0.61) | METAP2CCR1RAB9ACCR5PARP1 | |
| Neocuproine SCHEMBL11672280 | 0.75 | CCR1 (1.00) | METAP2CCR1RAB9ACCR5PARP1 | |
| Neocuproine SCHEMBL29367091 | 0.75 | CCR1 (1.00) | METAP2CCR1RAB9ACCR5PARP1 | |
| Neocuproine SCHEMBL124563 | 0.75 | CCR1 (1.00) | METAP2CCR1RAB9ACCR5PARP1 | |
| Neocuproine SCHEMBL29639703 | 0.75 | CCR1 (1.00) | METAP2CCR1RAB9ACCR5PARP1 | |
| SCHEMBL30019238 | 0.75 | METAP2 (0.55) | METAP2CCR1RAB9ACCR5PARP1 | |
| SCHEMBL14193973 | 0.75 | METAP2 (0.55) | METAP2CCR1RAB9ACCR5PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10005735-B2 | Inhibitors of RPN11 | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-06-26 | — | — | US | disclosed |
| EP-2516491-B1 | TI CATALYST SYSTEM COMPRISING SUBSTITUTED CYCLOPENTADIENYL, AMIDINE AND DIENE LIGAND | Arlanxeo Netherlands Bv (NL) | 2017-06-21 | — | — | EP | disclosed |
| WO-2017031255-A1 | INHIBITORS OF RPN11 | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2017-02-23 | — | — | WO | disclosed |
| US-20170050931-A1 | INHIBITORS OF RPN11 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-02-23 | — | — | US | disclosed |
| US-20170050931-A1 | INHIBITORS OF RPN11 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-02-23 | — | — | US | disclosed |
| US-9315594-B2 | Titanium-catalyst system comprising substituted cyclopentadienyl, guanidine and diene ligands | LANXESS ELASTOMERS B.V. (NL) | 2016-04-19 | — | — | US | disclosed |
| EP-1651690-B1 | PROCESS FOR THE PREPARATION OF A POLYOLEFIN | LANXESS ELASTOMERS BV (NL) | 2015-07-01 | — | — | EP | disclosed |
| US-8957170-B2 | Ti catalyst systems comprising substituted cyclopentadienyl, amidine and diene ligand | LANXESS DEUTSCHLAND GMBH (DE) | 2015-02-17 | — | — | US | disclosed |
| US-20140296458-A1 | TITANIUM-CATALYST SYSTEM COMPRISING SUBSTITUTED CYCLOPENTADIENYL, GUANIDINE AND DIENE LIGANDS | LANXESS ELASTOMERS B.V. (NL) | 2014-10-02 | — | — | US | disclosed |
| US-20140249283-A1 | BORANE ACTIVATED TITANIUM CATALYST SYSTEM COMPRISING GUANIDINE AND DIENE LIGANDS | LANXESS ELASTOMERS B.V. (NL) | 2014-09-04 | — | — | US | disclosed |
| WO-2005090418-A1 | POLIMERIZATION CATALYST COMPRISING AN AMIDINE LIGAND | DSM IP ASSETS B.V. (NL) | 2005-09-29 | — | — | WO | disclosed |
| EP-1535936-A1 | Improved method of preparing a hydrocarbylated metal-organic compound | DSM IP Assets B.V. (NL) | 2005-06-01 | — | — | EP | disclosed |
| WO-2005014664-A1 | PROCESS FOR THE PREPARATION OF A METAL-ORGANIC COMPOUND COMPRISING AT LEAST ONE IMINE LIGAND | DSM IP ASSETS B.V. (NL) | 2005-02-17 | — | — | WO | disclosed |
| WO-2005014601-A2 | PROCESS FOR THE PREPARATION OF A POLYOLEFIN | DSM IP ASSETS B.V. (NL) | 2005-02-17 | — | — | WO | disclosed |
| WO-2005014666-A1 | PROCESS FOR THE PREPARATION OF A METAL-ORGANIC COMPOUND COMPRISING AT LEAST ONE IMINE LIGAND | DSM IP ASSETS B.V. (NL) | 2005-02-17 | — | — | WO | disclosed |
| WO-2005014663-A1 | PROCESS FOR THE PREPARATION OF AN METALLOORGANIC COMPOUND COMPRISING AT LEAST ONE IMINE LIGAND | DSM IP ASSETS B.V. (NL) | 2005-02-17 | — | — | WO | disclosed |
| WO-2005014665-A1 | PROCESS FOR THE PREPARATION OF A METALLOORGANIC COMPOUND COMPRISING AT LEAST ONE IMINE LIGAND | DSM IP ASSETS B.V. (NL) | 2005-02-17 | — | — | WO | disclosed |
| WO-2005014669-A1 | IMPROVED METHOD OF PREPARING A HYDROCARBYLATED METAL-ORGANIC COMPOUND | DSM IP ASSETS B.V. (NL) | 2005-02-17 | — | — | WO | disclosed |
| WO-2005014674-A2 | PROCESS FOR THE PREPARATION OF A POLYOLEFIN | DSM IP ASSETS B.V. (NL) | 2005-02-17 | — | — | WO | disclosed |
| EP-1506974-A1 | Process for the preparation of a metalloorganic compound comprising at least one imine ligand | DSM IP Assets B.V. (NL) | 2005-02-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050931-A1 | INHIBITORS OF RPN11 | POLR2A, RPP30, RPIA | METAP2 4438/4885CCR1 3838/4885RAB9A 2455/4885 |
| US-10005735-B2 | Inhibitors of RPN11 | POLR2A, RPP30, RPIA | METAP2 4438/4885CCR1 3838/4885RAB9A 2455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.