Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | POLA1 | P09884 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.30 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19018668 | 0.82 | LMNA (0.33) | LMNATSHRHCAR2 | |
| SCHEMBL19187314 | 0.81 | — | — | |
| SCHEMBL27547653 | 0.80 | ALOX15 (0.33) | HSD17B10 | |
| SCHEMBL13176855 | 0.80 | ALOX15 (0.33) | HSD17B10 | |
| SCHEMBL13740265 | 0.78 | TSHR (0.30) | TSHR | |
| SCHEMBL13631097 | 0.74 | — | — | |
| SCHEMBL14367612 | 0.73 | MGAM (0.33) | ALDH1A1LMNAMGAMGAASI | |
| SCHEMBL22856027 | 0.72 | — | — | |
| SCHEMBL18533613 | 0.72 | PTPN1 (0.39) | ALDH1A1LMNAHSD17B10 | |
| SCHEMBL18532646 | 0.72 | GAA (0.37) | ALDH1A1MGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017127409-A1 | 2-OXINDOLE COMPOUNDS | CHEMOCENTRYX, INC. (US) | 2017-07-27 | — | — | WO | disclosed |
| US-20170204087-A1 | 2-OXINDOLE COMPOUNDS | CHEMOCENTRYX, INC. | 2017-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170204087-A1 | 2-OXINDOLE COMPOUNDS | CCR9, CCR1, CCRL2 | ALDH1A1 1553/4885LMNA 4300/4885MGAM 4565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.