Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17448206 | 0.87 | SMN1; SMN2 (0.45) | SMN1; SMN2RAB9ANPC1L3MBTL1HPGD | |
| SCHEMBL1755636 | 0.83 | KMT2A (0.49) | SMN1; SMN2RAB9ANPC1L3MBTL1HPGD | |
| SCHEMBL12452413 | 0.77 | RXFP1 (0.41) | SMN1; SMN2RAB9AL3MBTL1KMT2AMEN1 | |
| SCHEMBL18556671 | 0.77 | SLC6A2 (0.39) | L3MBTL1KMT2AMEN1MAPK1MAPT | |
| SCHEMBL20975935 | 0.76 | SMN1; SMN2 (0.47) | SMN1; SMN2RAB9ANPC1L3MBTL1HPGD | |
| SCHEMBL22106658 | 0.75 | KMT2A (0.58) | SMN1; SMN2RAB9AL3MBTL1HPGDKMT2A | |
| SCHEMBL8930757 | 0.75 | KMT2A (0.46) | SMN1; SMN2RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL22652916 | 0.74 | NAAA (0.45) | SMN1; SMN2KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL13755177 | 0.74 | MAPT (0.47) | SMN1; SMN2RAB9AL3MBTL1KMT2AMEN1 | |
| SCHEMBL7641621 | 0.72 | ALDH1A1 (0.52) | L3MBTL1HPGDKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170202974-A1 | LINKERS AND THEIR APPLICATION TOWARDS ADC | MEDSHINE DISCOVERY INC. (CN) | 2017-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170202974-A1 | LINKERS AND THEIR APPLICATION TOWARDS ADC | DNPEP, DPP7, DPP3 | SMN1; SMN2 2988/4885RAB9A 1974/4885NPC1 1216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.