Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | APP | P05067 | 2/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.46 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | SNCA | P37840 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19156093 | 0.95 | MAPT (0.55) | MAPTLMNASMN1; SMN2APPPTGDR2 | |
| SCHEMBL17971219 | 0.92 | MAPT (0.53) | MAPTLMNASMN1; SMN2APPPTGDR2 | |
| SCHEMBL17971223 | 0.86 | MAPT (0.50) | MAPTLMNASMN1; SMN2APPPTGDR2 | |
| SCHEMBL19156166 | 0.84 | MAPT (0.52) | MAPTLMNASMN1; SMN2APPPTGDR2 | |
| SCHEMBL16596241 | 0.83 | APP (0.53) | MAPTLMNASMN1; SMN2APPPTGDR2 | |
| SCHEMBL17958327 | 0.83 | APP (0.53) | MAPTLMNASMN1; SMN2APPPTGDR2 | |
| SCHEMBL16596307 | 0.81 | APP (0.51) | MAPTLMNASMN1; SMN2APPPTGDR2 | |
| SCHEMBL17971216 | 0.81 | APP (0.66) | MAPTLMNASMN1; SMN2APPPTGDR2 | |
| SCHEMBL16596257 | 0.78 | ENPP2 (0.51) | MAPTLMNASMN1; SMN2APPPTGDR2 | |
| SCHEMBL17971212 | 0.78 | APP (0.55) | MAPTLMNASMN1; SMN2APPPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9714240-B2 | Vinyl autotaxin inhibitor compounds | PHARMAKEA, INC. (US) | 2017-07-25 | — | — | US | disclosed |