Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 7/20 | 0.66 |
| ▸ | EGLN1 | Q9GZT9 | 7/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | PNP | P00491 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | ARG1 | P05089 | 2/20 | 0.32 |
| ▸ | ARG2 | P78540 | 2/20 | 0.32 |
| ▸ | FAAH | O00519 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL278429 | 0.79 | VEGFA (1.00) | VEGFAEGLN1HDAC8HDAC6HDAC1 | |
| SCHEMBL1772403 | 0.79 | VEGFA (1.00) | VEGFAEGLN1HDAC8HDAC6HDAC1 | |
| SCHEMBL21667235 | 0.68 | VEGFA (0.79) | VEGFAEGLN1KDM4EALDH1A1DRD2 | |
| SCHEMBL12598822 | 0.66 | VEGFA (0.84) | VEGFAEGLN1 | |
| SCHEMBL12598821 | 0.65 | EGLN1 (1.00) | VEGFAEGLN1 | |
| SCHEMBL17340686 | 0.64 | VEGFA (0.70) | VEGFAEGLN1KDM4EDRD2FAAH | |
| SCHEMBL12642706 | 0.64 | HDAC8 (0.67) | VEGFAEGLN1HDAC8HDAC6HDAC1 | |
| SCHEMBL14354649 | 0.63 | VEGFA (0.55) | VEGFAEGLN1HDAC8HDAC6HDAC1 | |
| SCHEMBL273125 | 0.63 | VEGFA (0.70) | VEGFAEGLN1ALDH1A1 | |
| SCHEMBL15314767 | 0.63 | VEGFA (0.68) | VEGFAEGLN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2853265-B1 | Methods for increasing the stabilization of hypoxia inducible factor-1 alpha | AERPIO THERAPEUTICS INC (US) | 2017-07-26 | — | — | EP | disclosed |