SCHEMBL1916232

SCHEMBL1916232

CN1C(=O)CCc2ncc(-c3ccccc3-c3csc(N(C(=O)[C@@H](CC(=O)O)CC4CCCC4)C4CC4)n3)cc21

nearest known ligand 0.68

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
FFAR2 O15552 11/20 0.68
SLC12A5 Q9H2X9 3/20 0.33
USP19 O94966 5/20 0.32
MMP2 P08253 1/20 0.30
MMP9 P14780 1/20 0.30
MMP12 P39900 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1916237 1.00 FFAR2 (0.68) FFAR2SLC12A5USP19MMP2MMP9
SCHEMBL1918331 0.94 FFAR2 (0.68) FFAR2SLC12A5USP19MMP2MMP9
SCHEMBL1918335 0.94 FFAR2 (0.68) FFAR2SLC12A5USP19MMP2MMP9
SCHEMBL1916544 0.90 FFAR2 (0.67) FFAR2SLC12A5USP19
SCHEMBL1916971 0.90 FFAR2 (0.67) FFAR2SLC12A5USP19MMP2MMP9
SCHEMBL1916978 0.90 FFAR2 (0.67) FFAR2SLC12A5USP19MMP2MMP9
SCHEMBL1916550 0.90 FFAR2 (0.67) FFAR2SLC12A5USP19
SCHEMBL16498237 0.89 FFAR2 (0.68) FFAR2SLC12A5USP19MMP2MMP9
SCHEMBL16498232 0.89 FFAR2 (0.68) FFAR2SLC12A5USP19MMP2MMP9
SCHEMBL1917470 0.89 FFAR2 (0.68) FFAR2SLC12A5USP19MMP2MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110230477-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS EUROSCREEN S.A. (BE) 2011-09-22 US claimed
WO-2011076734-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING INFLAMMATORY DISEASES EUROSCREEN S.A. (BE) 2011-06-30 WO claimed
WO-2011076732-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING GASTROINTESTINAL DISORDERS EUROSCREEN S.A. (BE) 2011-06-30 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230477-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS CPT1A, LIPC, PC FFAR2 295/4885SLC12A5 715/4885USP19 2831/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.