SCHEMBL1916319

SCHEMBL1916319

O=C(O)C[C@@H](CC1CCCC1)C(=O)N(c1nc(-c2cc(F)ccc2-c2ccc(N3CCCC3=O)nc2)cs1)C1CC1

nearest known ligand 0.64

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FFAR2 O15552 9/20 0.64
CNR2 P34972 1/20 0.34
USP19 O94966 1/20 0.33
KDM1A O60341 1/20 0.31
HCRTR1 O43613 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1916322 1.00 FFAR2 (0.64) FFAR2CNR2USP19KDM1AHCRTR1
SCHEMBL1916164 0.98 FFAR2 (0.63) FFAR2CNR2USP19HCRTR1
SCHEMBL1916167 0.98 FFAR2 (0.63) FFAR2CNR2USP19HCRTR1
SCHEMBL2398129 0.95 FFAR2 (0.57) FFAR2CNR2
SCHEMBL1917365 0.95 FFAR2 (0.57) FFAR2CNR2
SCHEMBL2452927 0.93 FFAR2 (0.58) FFAR2CNR2
SCHEMBL1915844 0.93 FFAR2 (0.57) FFAR2CNR2
SCHEMBL2398865 0.93 FFAR2 (0.57) FFAR2CNR2
SCHEMBL1917175 0.93 FFAR2 (0.61) FFAR2CNR2USP19
SCHEMBL2400007 0.93 FFAR2 (0.61) FFAR2CNR2USP19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110230477-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS EUROSCREEN S.A. (BE) 2011-09-22 US claimed
EP-2364297-A1 Compounds, pharmaceutical composition and methods for use in treating metabolic disorders Euroscreen S.A. (BE) 2011-09-14 EP claimed
WO-2011076734-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING INFLAMMATORY DISEASES EUROSCREEN S.A. (BE) 2011-06-30 WO claimed
WO-2011076732-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING GASTROINTESTINAL DISORDERS EUROSCREEN S.A. (BE) 2011-06-30 WO claimed
WO-2010066682-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS EUROSCREEN S.A. (BE) 2010-06-17 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230477-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS CPT1A, LIPC, PC FFAR2 295/4885CNR2 822/4885USP19 2831/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.