Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA5A | P35218 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.38 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6541115 | 0.78 | KMT2A (0.57) | CA1CA2CA5ACA9KMT2A | |
| SCHEMBL19181393 | 0.78 | CA1 (0.50) | CA1CA2CA5ACA9KMT2A | |
| SCHEMBL6627930 | 0.75 | CA1 (0.65) | CA1CA2CA5ACA9KMT2A | |
| SCHEMBL19180007 | 0.75 | SLC40A1 (0.56) | CA1CA2CA5ACA9KMT2A | |
| SCHEMBL7073806 | 0.72 | CA1 (0.52) | CA1CA2CA5ACA9KMT2A | |
| SCHEMBL1466405 | 0.72 | CA1 (0.52) | CA1CA2CA5ACA9KMT2A | |
| SCHEMBL9677113 | 0.72 | CA1 (0.59) | CA1CA2CA5ACA9KMT2A | |
| SCHEMBL6542414 | 0.72 | CA1 (0.49) | CA1CA2CA5ACA9KMT2A | |
| SCHEMBL15482281 | 0.72 | CA1 (0.49) | CA1CA2CA5ACA9KMT2A | |
| SCHEMBL25221412 | 0.71 | GAA (0.76) | KMT2AGAANPSR1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240092802-A1 | MU-OPIOID RECEPTOR AGONISTS AND USES THEREFOR | KURES, INC. | 2024-03-21 | — | — | US | disclosed |
| EP-3116509-B1 | A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | UNIV COLUMBIA (US) | 2022-06-22 | — | — | EP | disclosed |
| US-20220106279-A1 | CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2022-04-07 | — | — | US | disclosed |
| US-20220106279-A1 | CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2022-04-07 | — | — | US | disclosed |
| US-20190084949-A1 | NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-03-21 | — | — | US | disclosed |
| US-20190084949-A1 | NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-03-21 | — | — | US | disclosed |
| US-10183919-B2 | Class of mu-opioid receptor agonists | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-01-22 | — | — | US | disclosed |
| US-10183919-B2 | Class of mu-opioid receptor agonists | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-01-22 | — | — | US | disclosed |
| US-20170217913-A1 | A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-08-03 | — | — | US | disclosed |
| US-20170217913-A1 | A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-08-03 | — | — | US | disclosed |
| US-20170217913-A1 | A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240092802-A1 | MU-OPIOID RECEPTOR AGONISTS AND USES THEREFOR | OPRL1, OPRM1, CDKL5 | CA1 4222/4885CA2 4303/4885CA5A 1055/4885 |
| US-10183919-B2 | Class of mu-opioid receptor agonists | OPRM1, OPRL1, OPRK1 | CA1 3391/4885CA2 2065/4885CA5A 2711/4885 |
| US-20220106279-A1 | CLASS OF MU-OPIOID RECEPTOR AGONISTS | OPRM1, OPRL1, OPRK1 | CA1 3391/4885CA2 2065/4885CA5A 2711/4885 |
| US-20190084949-A1 | NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | OPRM1, OPRL1, OPRK1 | CA1 4040/4885CA2 2927/4885CA5A 2987/4885 |
| US-20170217913-A1 | A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | OPRM1, OPRL1, OPRK1 | CA1 4029/4885CA2 2533/4885CA5A 2917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.