Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GZMB | P10144 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 7/20 | 0.34 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19181362 | 1.00 | GZMB (0.36) | GZMBRORCSCN9ACXCR3CALCRL | |
| SCHEMBL19181365 | 1.00 | GZMB (0.36) | GZMBRORCSCN9ACXCR3CALCRL | |
| SCHEMBL19180980 | 0.94 | GZMB (0.36) | GZMBRORCSCN9ACXCR3CALCRL | |
| SCHEMBL19180973 | 0.94 | GZMB (0.36) | GZMBRORCSCN9ACXCR3CALCRL | |
| SCHEMBL19180866 | 0.91 | CXCR3 (0.38) | GZMBRORCSCN9ACXCR3HDAC8 | |
| SCHEMBL19180865 | 0.91 | CXCR3 (0.38) | GZMBRORCSCN9ACXCR3HDAC8 | |
| SCHEMBL19180867 | 0.91 | CXCR3 (0.38) | GZMBRORCSCN9ACXCR3HDAC8 | |
| SCHEMBL19180858 | 0.90 | CXCR3 (0.37) | GZMBRORCSCN9ACXCR3CYP3A4 | |
| SCHEMBL19180854 | 0.90 | CXCR3 (0.37) | GZMBRORCSCN9ACXCR3CYP3A4 | |
| SCHEMBL17600514 | 0.89 | XIAP (0.41) | GZMBCXCR3CYP3A4ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200062803-A1 | AZAINDOLINE COMPOUNDS AS GRANZYME B INHIBITORS | VIDA THERAPEUTICS INC. (CA) | 2020-02-27 | — | — | US | disclosed |
| US-10246487-B2 | Azaindoline compounds as granzyme B inhibitors | VIDA THERAPEUTICS INC. (CA) | 2019-04-02 | — | — | US | disclosed |
| US-20170218014-A1 | AZAINDOLINE COMPOUNDS AS GRANZYME B INHIBITORS | VIDA THERAPEUTICS INC. (CA) | 2017-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170218014-A1 | AZAINDOLINE COMPOUNDS AS GRANZYME B INHIBITORS | GZMB, DNASE1L3, DNASE1 | GZMB 1/4885RORC 3743/4885SCN9A 2377/4885 |
| US-10246487-B2 | Azaindoline compounds as granzyme B inhibitors | GZMB, DNASE1L3, DNASE1 | GZMB 1/4885RORC 3743/4885SCN9A 2377/4885 |
| US-20200062803-A1 | AZAINDOLINE COMPOUNDS AS GRANZYME B INHIBITORS | GZMB, DNASE1L3, DNASE1 | GZMB 1/4885RORC 3743/4885SCN9A 2377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.