Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | CASP1 | P29466 | 3/20 | 0.32 |
| ▸ | CASP7 | P55210 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GRK6 | P43250 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1302206 | 0.89 | TLR7 (0.49) | TLR7TLR8ALDH1A1MAPK1KDM4E | |
| SCHEMBL19181987 | 0.84 | ALDH1A1 (0.36) | TLR7TLR8ALDH1A1MAPK1KDM4E | |
| SCHEMBL1300750 | 0.80 | TLR7 (0.41) | TLR7ALDH1A1MAPK1KDM4EMAPT | |
| SCHEMBL14758128 | 0.78 | TLR7 (0.51) | TLR7TLR8ALDH1A1MAPK1KDM4E | |
| SCHEMBL19475180 | 0.77 | ALDH1A1 (0.37) | TLR7TLR8ALDH1A1MAPK1KDM4E | |
| SCHEMBL19180239 | 0.74 | TLR7 (0.38) | TLR7TLR8ALDH1A1MAPTLMNA | |
| SCHEMBL1301869 | 0.73 | ALDH1A1 (0.39) | TLR7TLR8ALDH1A1MAPK1KDM4E | |
| SCHEMBL1302080 | 0.72 | TLR7 (0.44) | TLR7ALDH1A1MAPK1HPGDLMNA | |
| SCHEMBL19180241 | 0.69 | TLR7 (0.41) | TLR7TLR8ALDH1A1MAPTMEN1 | |
| SCHEMBL1301770 | 0.69 | TLR7 (0.46) | TLR7TLR8ALDH1A1MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220289744-A1 | IMMUNOMODULATORS AND IMMUNOMODULATOR CONJUGATES | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2022-09-15 | — | — | US | disclosed |
| US-11279701-B2 | Immunomodulators and immunomodulator conjugates | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2022-03-22 | — | — | US | disclosed |
| US-11279701-B2 | Immunomodulators and immunomodulator conjugates | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2022-03-22 | — | — | US | disclosed |
| US-20200325136-A1 | IMMUNOMODULATORS AND IMMUNOMODULATOR CONJUGATES | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2020-10-15 | — | — | US | disclosed |
| US-20200325136-A1 | IMMUNOMODULATORS AND IMMUNOMODULATOR CONJUGATES | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2020-10-15 | — | — | US | disclosed |
| US-10730871-B2 | Immunomodulators and immunomodulator conjugates | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2020-08-04 | — | — | US | disclosed |
| US-10730871-B2 | Immunomodulators and immunomodulator conjugates | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2020-08-04 | — | — | US | disclosed |
| US-20170217960-A1 | IMMUNOMODULATORS AND IMMUNOMODULATOR CONJUGATES | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2017-08-03 | — | — | US | disclosed |
| US-20170217960-A1 | IMMUNOMODULATORS AND IMMUNOMODULATOR CONJUGATES | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2017-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10730871-B2 | Immunomodulators and immunomodulator conjugates | CD40, CD47, FCGRT | TLR7 124/4885TLR8 184/4885ALDH1A1 197/4885 |
| US-20220289744-A1 | IMMUNOMODULATORS AND IMMUNOMODULATOR CONJUGATES | CD47, IL2, ICOS | TLR7 65/4885TLR8 58/4885ALDH1A1 431/4885 |
| US-11279701-B2 | Immunomodulators and immunomodulator conjugates | IL2, CD47, FCGRT | TLR7 44/4885TLR8 99/4885ALDH1A1 596/4885 |
| US-20170217960-A1 | IMMUNOMODULATORS AND IMMUNOMODULATOR CONJUGATES | CD47, CD40, HLA-DRB1 | TLR7 115/4885TLR8 150/4885ALDH1A1 149/4885 |
| US-20200325136-A1 | IMMUNOMODULATORS AND IMMUNOMODULATOR CONJUGATES | IL2, CD47, FCGRT | TLR7 44/4885TLR8 99/4885ALDH1A1 596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.