Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 2/20 | 0.41 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.40 |
| ▸ | P2RY1 | P47900 | 6/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | P2RY11 | Q96G91 | 2/20 | 0.38 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.38 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.37 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.37 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19187036 | 0.93 | NT5E (0.41) | NT5EFUT5P2RY1ENPP1P2RY12 | |
| SCHEMBL23010227 | 0.91 | NT5E (0.38) | NT5EP2RY1P2RY11 | |
| SCHEMBL19827628 | 0.89 | NT5E (0.38) | NT5EFUT5P2RY1ENPP1P2RY12 | |
| SCHEMBL19827534 | 0.88 | NT5E (0.36) | NT5EFUT5P2RY1ENPP1P2RY12 | |
| SCHEMBL20056907 | 0.84 | NT5E (0.40) | NT5EFUT5P2RY1ENPP1P2RY11 | |
| SCHEMBL19827565 | 0.84 | NT5E (0.38) | NT5EFUT5P2RY1ENPP1P2RY12 | |
| SCHEMBL20056910 | 0.84 | NT5E (0.38) | NT5EP2RY1P2RY11 | |
| SCHEMBL19827632 | 0.83 | CA5A (0.44) | NT5EP2RY1P2RY11P2RX3IMPDH2 | |
| SCHEMBL16024938 | 0.83 | P2RY1 (0.48) | FUT5P2RY1ENPP1P2RY12P2RY11 | |
| SCHEMBL19827519 | 0.82 | NT5E (0.37) | NT5EFUT5P2RY1ENPP1P2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2696679-B1 | 2'-CYANO SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME (US) | 2017-08-02 | — | — | EP | disclosed |