Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.52 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 9/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 9/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2810641 | 0.86 | PIM1 (0.56) | PIM1BCAT1HSD11B1TAS1R3TAS1R1 | |
| SCHEMBL1936455 | 0.80 | NAMPT (0.39) | PIM1BCAT1HSD11B1KDM4EALDH1A1 | |
| SCHEMBL7799411 | 0.76 | HSD11B1 (0.49) | PIM1HSD11B1TAS1R3TAS1R1KDM4E | |
| SCHEMBL17179765 | 0.76 | PIM1 (0.68) | PIM1BCAT1KDM4EALDH1A1GAA | |
| SCHEMBL9989806 | 0.75 | TAS1R3 (0.63) | BCAT1TAS1R3TAS1R1CA2 | |
| SCHEMBL9989805 | 0.75 | TAS1R3 (0.63) | BCAT1TAS1R3TAS1R1CA2 | |
| SCHEMBL2370509 | 0.74 | KMT2A (0.48) | HSD11B1KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL7799412 | 0.72 | FFAR4 (0.57) | PIM1HSD11B1KDM4EALDH1A1CA2 | |
| SCHEMBL13724073 | 0.72 | FLT3 (0.67) | PIM1TAS1R3TAS1R1KDM4EALDH1A1 | |
| SCHEMBL29431703 | 0.72 | KDM4E (0.68) | KDM4EALDH1A1GAAHPGDCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2545042-A1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | Bristol-Myers Squibb Company (US) | 2013-01-16 | — | — | EP | disclosed |
| WO-2011112191-A1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-09-15 | — | — | WO | disclosed |
| EP-2326633-A1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | Bristol-Myers Squibb Company (US) | 2011-06-01 | — | — | EP | disclosed |