Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 1/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.58 |
| ▸ | PARP1 | P09874 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19188092 | 0.88 | MMP12 (0.62) | MMP12KDM4ERAB9ANPC1MAPT | |
| SCHEMBL279594 | 0.87 | MMP12 (1.00) | MMP12KDM4ERAB9ANPC1MAPT | |
| SCHEMBL4267366 | 0.87 | MMP12 (0.70) | MMP12KDM4ERAB9ANPC1MAPT | |
| SCHEMBL304764 | 0.86 | MAPT (0.62) | MMP12KDM4EMAPTNR3C2PARP1 | |
| SCHEMBL5214057 | 0.83 | ALDH1A1 (0.60) | MMP12KDM4ERAB9ANPC1MAPT | |
| SCHEMBL4264682 | 0.81 | MMP12 (0.58) | MMP12KDM4ERAB9ANPC1MAPT | |
| SCHEMBL4267784 | 0.81 | PKM (0.59) | MMP12KDM4ERAB9ANPC1MAPT | |
| SCHEMBL14423461 | 0.81 | MMP12 (0.54) | MMP12KDM4ERAB9ANPC1MAPT | |
| SCHEMBL4271023 | 0.81 | MMP12 (0.70) | MMP12RAB9ANR3C2PARP1DRD2 | |
| SCHEMBL4259548 | 0.80 | POLB (0.78) | MMP12KDM4ERAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2758398-B1 | SUBSTITUTED N- [1-CYANO-2- (PHENYL) ETHYL]-2-AZABICYCLO [2.2.1]HEPTANE-3-CARBOXAMIDE INHIBITORS OF CATHEPSIN C | BOEHRINGER INGELHEIM INT (DE) | 2017-08-02 | — | — | EP | disclosed |