Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2695965 | 0.77 | MET (0.60) | MET | |
| SCHEMBL18061173 | 0.74 | MET (0.48) | METCYP3A4 | |
| SCHEMBL9910476 | 0.70 | MET (0.81) | METCYP3A4 | |
| Bromide SCHEMBL2699721 | 0.70 | MET (0.79) | METCYP3A4 | |
| SCHEMBL13772484 | 0.67 | MET (0.49) | MET | |
| SCHEMBL19190560 | 0.66 | MET (0.60) | MET | |
| SCHEMBL2699919 | 0.65 | MET (0.64) | METCYP3A4 | |
| SCHEMBL14848256 | 0.63 | MET (0.46) | METCYP3A4 | |
| SCHEMBL19190876 | 0.62 | MET (0.62) | MET | |
| SCHEMBL4299513 | 0.61 | KDM4E (0.43) | METTLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231663-B1 | 6-([1,2,4]TRIAZOLO[4,3-A]PYRIDIN-3-YLMETHYL)-1,6-NAPHTHYRIDIN-5(6H)-ONE DERIVATIVES AS C-MET INHIBITORS | AMGEN INC (US) | 2017-08-02 | — | — | EP | disclosed |