Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.55 |
| ▸ | CTSS | P25774 | 5/20 | 0.50 |
| ▸ | CTSK | P43235 | 5/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 3/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29253632 | 0.86 | BACE1 (0.59) | ATMCTSSCTSKCA12CA1 | |
| SCHEMBL30279569 | 0.86 | BACE1 (0.59) | ATMCTSSCTSKCA12CA1 | |
| SCHEMBL2393583 | 0.86 | BACE1 (0.59) | ATMCTSSCTSKCA12CA1 | |
| SCHEMBL24347009 | 0.84 | BACE1 (0.60) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL5738490 | 0.83 | CTSS (0.51) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL4212585 | 0.83 | CTSK (0.62) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL4632779 | 0.83 | CA12 (0.60) | ATMCTSSCTSKCA12CA1 | |
| SCHEMBL6842587 | 0.82 | CTSS (0.53) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL7984152 | 0.82 | CTSS (0.53) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL6842589 | 0.82 | CTSS (0.53) | ATMCTSSCTSKCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2771337-B1 | 3-(PYRIMIDIN-4-YL)-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH | NOVARTIS AG (CH) | 2017-08-02 | — | — | EP | disclosed |