Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 4/20 | 0.63 |
| ▸ | HTR6 | P50406 | 3/20 | 0.60 |
| ▸ | MTNR1A | P48039 | 9/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.54 |
| ▸ | NQO2 | P16083 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7496635 | 0.88 | ALDH1A1 (0.51) | ADRB2HTR6MTNR1AMTNR1BNQO2 | |
| SCHEMBL13888101 | 0.81 | ADRB2 (0.70) | ADRB2HTR6MTNR1AMTNR1BNQO2 | |
| SCHEMBL1093061 | 0.81 | ADRB2 (0.65) | ADRB2HTR6MTNR1AMTNR1BNQO2 | |
| SCHEMBL14041509 | 0.80 | HTR6 (0.48) | ADRB2HTR6MTNR1AMTNR1BNQO2 | |
| SCHEMBL2726199 | 0.80 | AKR1C3 (0.66) | HTR6MTNR1AMTNR1BNQO2RAB9A | |
| SCHEMBL12185393 | 0.79 | ADRB2 (0.76) | ADRB2HTR6MTNR1AMTNR1BNQO2 | |
| SCHEMBL6261747 | 0.79 | ADRB2 (0.67) | ADRB2HTR6MTNR1AMTNR1BNQO2 | |
| SCHEMBL10577553 | 0.79 | ADRB2 (0.44) | ADRB2HTR6MTNR1AMTNR1BNQO2 | |
| SCHEMBL6245487 | 0.79 | CYP2A6 (0.48) | ADRB2HTR6MEN1POLBRAB9A | |
| SCHEMBL13015284 | 0.79 | ALDH1A1 (0.49) | ADRB2HTR6MEN1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445497-B1 | Use of derivatives of indoles for the treatment of cancer | CENTRE NAT DE LA RECH SCIENT (C N R S ) (FR) | 2017-08-02 | — | — | EP | disclosed |