⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31330009 | 0.77 | — | — | |
| SCHEMBL29385092 | 0.75 | RAPGEF4 (0.31) | — | |
| SCHEMBL6026196 | 0.75 | RAPGEF4 (0.31) | — | |
| SCHEMBL286168 | 0.75 | RAPGEF4 (0.31) | — | |
| SCHEMBL6188413 | 0.73 | — | — | |
| SCHEMBL2110353 | 0.71 | ALDH1A1 (0.34) | — | |
| SCHEMBL2494786 | 0.70 | — | — | |
| SCHEMBL6026676 | 0.70 | — | — | |
| SCHEMBL20488793 | 0.68 | — | — | |
| SCHEMBL191365 | 0.67 | ALDH1A1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102333781-B | Tricyclic pyrazolopyrimidine derivatives | DAIICHI SANKYO CO LTD | 2014-06-11 | — | — | CN | disclosed |
| CN-103261167-A | Substituted 6,6-used nitrogenous heterocyclic compounds and uses thereof | HOFFMANN LA ROCHE | 2013-08-21 | — | — | CN | disclosed |
| US-8445504-B2 | Tricyclic pyrazolopyrimidine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-05-21 | — | — | US | disclosed |
| US-20120202833-A1 | TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-08-09 | — | — | US | disclosed |
| US-8236813-B2 | Tricyclic pyrazolopyrimidine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-08-07 | — | — | US | disclosed |
| CN-102333781-A | Tricyclic pyrazolopyrimidine derivatives | DAIICHI SANKYO CO LTD | 2012-01-25 | — | — | CN | disclosed |
| EP-2402349-A1 | TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2012-01-04 | — | — | EP | disclosed |
| US-20110071170-A1 | TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-03-24 | — | — | US | disclosed |