Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.45 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19200535 | 0.86 | CES2 (0.40) | MEN1ALDH1A1LMNAKMT2ANR3C2 | |
| SCHEMBL20696322 | 0.86 | CES2 (0.40) | MEN1ALDH1A1LMNAKMT2ANPY2R | |
| SCHEMBL19182797 | 0.84 | LMNA (0.45) | LMNANPY2RCES2CES1SLC6A2 | |
| SCHEMBL15063187 | 0.79 | GAA (0.50) | MEN1ALDH1A1LMNAKMT2ANPY2R | |
| SCHEMBL31560789 | 0.79 | CES2 (0.46) | ALDH1A1NR3C2CES2CES1RAB9A | |
| SCHEMBL31117167 | 0.79 | CES2 (0.46) | ALDH1A1NR3C2CES2CES1RAB9A | |
| SCHEMBL15797720 | 0.78 | CHRNB2 (0.42) | MEN1ALDH1A1KMT2ANPY2RCES2 | |
| SCHEMBL15063231 | 0.77 | LMNA (0.71) | MEN1ALDH1A1LMNAKMT2ANR3C2 | |
| SCHEMBL8595608 | 0.75 | CES2 (0.58) | LMNANR3C2CES2CES1RAB9A | |
| SCHEMBL6400373 | 0.75 | CES2 (0.58) | LMNANR3C2CES2CES1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017131221-A1 | INDANE DERIVATIVES AS MGLUR7 MODULATORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-08-03 | — | — | WO | disclosed |