Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17506002 | 0.82 | BLM (0.51) | SMN1; SMN2RAB9AHPGDPOLBMEN1 | |
| SCHEMBL17506004 | 0.82 | BLM (0.51) | SMN1; SMN2RAB9AHPGDPOLBMEN1 | |
| SCHEMBL17505997 | 0.82 | RAB9A (0.58) | SMN1; SMN2NPC1RAB9AEPHX1HPGD | |
| SCHEMBL17505996 | 0.82 | RAB9A (0.58) | SMN1; SMN2NPC1RAB9AEPHX1HPGD | |
| SCHEMBL19201099 | 0.80 | RAB9A (0.51) | SMN1; SMN2NPC1RAB9AEPHX1HPGD | |
| SCHEMBL17506010 | 0.78 | CASR (0.57) | NPC1RAB9AEPHX1MAPTNPSR1 | |
| SCHEMBL17506011 | 0.78 | CASR (0.57) | NPC1RAB9AEPHX1MAPTNPSR1 | |
| SCHEMBL19181332 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2HPGDMAPTPOLBMEN1 | |
| SCHEMBL17506009 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2HPGDMAPTPOLBMEN1 | |
| SCHEMBL17506001 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2HPGDMAPTPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170217914-A1 | Novel Triarylethylene Compounds and Methods Using Same | THE PENN STATE RESEARCH FOUNDATION | 2017-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217914-A1 | Novel Triarylethylene Compounds and Methods Using Same | CYP46A1, GSTA2, GSTA1 | SMN1; SMN2 3107/4885NPC1 23/4885RAB9A 2537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.