Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRPS1 | P60891 | 2/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.43 |
| ▸ | KRAS | P01116 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2592735 | 0.82 | PRPS1 (0.39) | PRPS1NR4A2L3MBTL1 | |
| SCHEMBL497718 | 0.79 | NR4A2 (0.63) | PRPS1NR4A2KMT2AMEN1L3MBTL1 | |
| SCHEMBL7512469 | 0.78 | LMNA (0.58) | KMT2AMEN1PIK3CDPIK3R1PIK3CA | |
| SCHEMBL29576838 | 0.78 | LMNA (0.58) | KMT2AMEN1PIK3CDPIK3R1PIK3CA | |
| SCHEMBL29576694 | 0.77 | KDM4E (0.59) | KMT2AMEN1PIK3CDPIK3R1PIK3CA | |
| SCHEMBL7578838 | 0.77 | KDM4E (0.59) | KMT2AMEN1PIK3CDPIK3R1PIK3CA | |
| SCHEMBL2596068 | 0.77 | OPRK1 (0.42) | PRPS1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL498716 | 0.76 | PRPS1 (0.45) | PRPS1NR4A2KRASKMT2AMEN1 | |
| SCHEMBL21549969 | 0.76 | NR4A2 (0.66) | PRPS1NR4A2KRASKMT2AMEN1 | |
| SCHEMBL35211208 | 0.76 | NR4A2 (0.66) | PRPS1NR4A2KRASKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017128896-A1 | FXR AGONIST AND PREPARATION METHOD AND USE THEREOF | 江苏豪森药业集团有限公司 | 2017-08-03 | — | — | WO | disclosed |