Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 10/20 | 0.63 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1096716 | 0.84 | NR4A2 (0.44) | NR4A2BRD4KMT2ALMNAALDH1A1 | |
| SCHEMBL5246371 | 0.83 | NR4A2 (0.65) | NR4A2BRD4KMT2AMEN1LMNA | |
| SCHEMBL1097177 | 0.83 | KMT2A (0.47) | NR4A2KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL497718 | 0.82 | NR4A2 (0.63) | NR4A2BRD4KMT2AMEN1LMNA | |
| SCHEMBL5243737 | 0.82 | NR4A2 (0.63) | NR4A2BRD4KMT2ALMNAALDH1A1 | |
| SCHEMBL7501910 | 0.79 | ALDH1A1 (0.40) | NR4A2KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL25742163 | 0.78 | LMNA (0.43) | NR4A2KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL9769280 | 0.78 | NR4A2 (0.58) | NR4A2BRD4KMT2AMEN1LMNA | |
| SCHEMBL25742160 | 0.78 | LMNA (0.46) | NR4A2KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL1092934 | 0.78 | NR4A2 (1.00) | NR4A2BRD4KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020249064-A1 | COMPOUNDS FOR MODULATING FXR | NANJING RUIJIE PHARMA CO., LTD. (CN) | 2020-12-17 | — | — | WO | disclosed |
| WO-2017128896-A1 | FXR AGONIST AND PREPARATION METHOD AND USE THEREOF | 江苏豪森药业集团有限公司 | 2017-08-03 | — | — | WO | disclosed |