Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Cholesterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OSBP | P22059 | 6/20 | 0.91 |
| ▸ | RORC | P51449 | 5/20 | 0.91 |
| ▸ | OSBP2 | Q969R2 | 3/20 | 0.91 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.91 |
| ▸ | USP2 | O75604 | 1/20 | 0.91 |
| ▸ | LMNA | P02545 | 1/20 | 0.91 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.91 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.78 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.78 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.77 |
| ▸ | CRYAB | P02511 | 1/20 | 0.74 |
| ▸ | HMGCR | P04035 | 1/20 | 0.74 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.74 |
| ▸ | ITGAV | P06756 | 1/20 | 0.74 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.74 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.74 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.73 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.72 |
| ▸ | DHCR24 | Q15392 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cholesterol SCHEMBL29094044 | 1.00 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL9458834 | 1.00 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL26086800 | 1.00 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL1965451 | 1.00 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL27579873 | 1.00 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL159924 | 0.99 | OSBP (0.89) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL21879229 | 0.99 | OSBP (0.89) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL2160402 | 0.99 | OSBP (0.89) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL3792432 | 0.99 | OSBP (0.89) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL27237461 | 0.99 | OSBP (0.89) | OSBPRORCOSBP2CYP46A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5210 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026101699-A1 | LIPID NANOPARTICLE FORMULATIONS, AND METHODS OF USE THEREOF | R.P. SCHERER TECHNOLOGIES, LLC (US) | 2026-05-15 | — | — | WO | claimed |
| WO-2026099917-A1 | METHOD FOR PRODUCING USEFUL SUBSTANCE, CULTURE SOLUTION FOR CULTURING ALGAE, AND DEVICE FOR PRODUCING USEFUL SUBSTANCE | ＮＴＴ株式会社 | 2026-05-15 | — | — | WO | claimed |
| WO-2026100273-A1 | METHOD FOR PRODUCING USEFUL SUBSTANCE, CULTURE SOLUTION FOR CULTURING ALGAE, APPARATUS FOR PRODUCING USEFUL SUBSTANCE, AND ALGAE CONTAINING USEFUL SUBSTANCE | ＮＴＴ株式会社 | 2026-05-15 | — | — | WO | claimed |
| EP-4734964-A1 | LIPID PARTICLES FOR DELIVERING A PAYLOAD | Repertoire Immune Medicines, Inc. (US) | 2026-05-06 | — | — | EP | claimed |
| WO-2026089660-A1 | A PLATFORM FOR MIMICKING BIOLOGICAL AIR-INTERFACES | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2026-04-30 | — | — | WO | claimed |
| EP-4731197-A1 | LIPOSOMAL-BASED COMPOSITION | Consejo Superior De Investigaciones Científicas (ES) | 2026-04-29 | — | — | EP | claimed |
| US-12599547-B2 | Topical compositions optimised for epidermal lipids and phosphatidyl gycerol | UNIFARCO S.P.A. (IT) | 2026-04-14 | — | — | US | claimed |
| US-20250302721-A1 | ANTI-AGING EYE CREAM | L'OREAL (FR) | 2025-10-02 | — | — | US | claimed |
| WO-2025202997-A1 | AN ANTI-AGING EYE CREAM | L'OREAL (FR) | 2025-10-02 | — | — | WO | claimed |
| US-20250268814-A1 | SIMULATED VERNIX COMPOSITION AND EMULSION INCLUDING THE SAME | Dermegen Inc. (US) | 2025-08-28 | — | — | US | claimed |
| WO-1990006775-A1 | A NOVEL NONPHOSPHOLIPID LIPOSOME COMPOSITION FOR SUSTAINED RELEASE OF DRUGS | LIPOSOME TECHNOLOGY, INC. (US) | 1990-06-28 | — | — | WO | claimed |
| US-4906477-A | Antineoplastic agent-entrapping liposomes | KABUSHIKI KAISHA VITAMIN KENKYUSYO (JP) | 1990-03-06 | — | — | US | claimed |
| US-4906476-A | Novel liposome composition for sustained release of steroidal drugs in lungs | LIPOSOME TECHNOLOGY, INC. | 1990-03-06 | — | — | US | claimed |
| WO-1990001323-A1 | METHOD AND COMPOSITION FOR TREATING AND PREVENTING DRY SKIN DISORDERS | BERNSTEIN JOEL E (US) | 1990-02-22 | — | — | WO | claimed |
| EP-0303683-A4 | AMPHOTERICIN B/CHOLESTEROL SULFATE COMPOSITION AND METHOD. | LIPOSOME TECHNOLOGY INC (US) | 1989-12-28 | — | — | EP | claimed |
| US-4822777-A | MORE STABLE PARTICLE SIZE, LESS TOXIC | LIPOSOME TECHNOLOGY, INC. (US) | 1989-04-18 | — | — | US | claimed |
| EP-0303683-A1 | AMPHOTERICIN B/CHOLESTEROL SULFATE COMPOSITION AND METHOD. | LIPOSOME TECHNOLOGY INC (US) | 1989-02-22 | — | — | EP | claimed |
| US-4780455-A | PHOSPHOLIPIDS OR STEARINS WITH CHOLESTEROL SULFATE OR SODIUM CHOLESTEROL SULFATE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 1988-10-25 | — | — | US | claimed |
| WO-1988006450-A1 | AMPHOTERICIN B/CHOLESTEROL SULFATE COMPOSITION AND METHOD | LIPOSOME TECHNOLOGY, INC. (US) | 1988-09-07 | — | — | WO | claimed |
| EP-0278465-A1 | Antineoplastic agent-entrapping liposomes | Kabushiki Kaisha Vitamin Kenkyusyo (JP) | 1988-08-17 | — | — | EP | claimed |