Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Cholesterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OSBP | P22059 | 6/20 | 0.89 |
| ▸ | RORC | P51449 | 5/20 | 0.89 |
| ▸ | OSBP2 | Q969R2 | 3/20 | 0.89 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.89 |
| ▸ | USP2 | O75604 | 1/20 | 0.89 |
| ▸ | LMNA | P02545 | 1/20 | 0.89 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.89 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.76 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.76 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.75 |
| ▸ | CRYAB | P02511 | 1/20 | 0.73 |
| ▸ | HMGCR | P04035 | 1/20 | 0.73 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.73 |
| ▸ | ITGAV | P06756 | 1/20 | 0.73 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.73 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.73 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.72 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.71 |
| ▸ | DHCR24 | Q15392 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cholesterol SCHEMBL28152609 | 1.00 | OSBP (0.89) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL192030 | 0.99 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL26086800 | 0.99 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL9458834 | 0.99 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL27579873 | 0.99 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL29094044 | 0.99 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL1965451 | 0.99 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL21879229 | 0.98 | OSBP (0.89) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL2160402 | 0.98 | OSBP (0.89) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL3792432 | 0.98 | OSBP (0.89) | OSBPRORCOSBP2CYP46A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 389 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120053371-A | Aprepitant micelle injection and preparation method thereof | 济南大学 | 2025-05-30 | — | — | CN | claimed |
| CN-120053640-A | Ion pairing engineering nanometer assembly of type I and type II immunogenic cell death inducer, construction and application thereof | 沈阳药科大学 | 2025-05-30 | — | — | CN | claimed |
| CN-119855952-A | Sizing agent comprising functionalized polyolefin | SABIC环球技术有限责任公司 | 2025-04-18 | — | — | CN | claimed |
| CN-119424667-A | Cholesterol derivative pharmaceutical composition and preparation method and application thereof | 沈阳药科大学 | 2025-02-14 | — | — | CN | claimed |
| CN-119385945-A | Targeted nano liposome based on field Huang Gangan, and preparation method and application thereof | 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） | 2025-02-07 | — | — | CN | claimed |
| CN-117630395-B | Whole blood composite quality control product for microfluidic biochemical analysis chip | 阿里生物技术泰州有限公司 | 2024-12-27 | — | — | CN | claimed |
| CN-119019747-A | Through-hole hydrogel for medical facial mask | 成都大学 | 2024-11-26 | — | — | CN | claimed |
| WO-2024222862-A1 | LYOPHILIZED TANGERETIN NANO-LIPOSOME FORMULATION AND METHOD FOR PREPARING SAME | 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） | 2024-10-31 | — | — | WO | claimed |
| CN-118619862-A | Mitoxantrone-fatty alcohol prodrug and nano-electrostatic complex thereof and preparation method | 沈阳药科大学 | 2024-09-10 | — | — | CN | claimed |
| CN-115137713-B | Amphotericin B aerosol inhalation preparation and preparation method thereof | 北京新领先医药科技发展有限公司 | 2024-08-02 | — | — | CN | claimed |
| CN-101439033-A | Polyenic taxusol lipid complexes and micelle composition thereof for injection | SHENYANG WOSEN PHARMACEUTICAL (CN) | 2009-05-27 | — | — | CN | claimed |
| CN-101439032-A | Paclitaxel lipid complexes and micelle composition thereof for injection | SHENYANG WOSEN PHARMACEUTICAL (CN) | 2009-05-27 | — | — | CN | claimed |
| CN-101322690-A | Stable medicament lipid complexes | GUANGZHOU RUIJI BIOTECHNOLOGY (CN) | 2008-12-17 | — | — | CN | claimed |
| CN-101002733-A | Stable elaioplast composition | AILISI MEDICINE TECH CO LTD SH (CN) | 2007-07-25 | — | — | CN | claimed |
| CN-1256092-C | Methyleritrocina injection | GUANGZHOU RUIJI BIOLOG TECHNOL (CN) | 2006-05-17 | — | — | CN | claimed |
| CN-1552339-A | Methyleritrocina injection | 广州瑞济生物技术有限公司 | 2004-12-08 | — | — | CN | claimed |
| CN-1380064-A | Method for producing antibiotic preparation and its application | HERAEUS GUSA GMBH & CO KG (DE) | 2002-11-20 | — | — | CN | claimed |
| US-5049389-A | Non-phospholipd lipid, delivery by inhalation | LIPOSOME TECHNOLOGY, INC. (US) | 1991-09-17 | — | — | US | claimed |
| WO-1990006775-A1 | A NOVEL NONPHOSPHOLIPID LIPOSOME COMPOSITION FOR SUSTAINED RELEASE OF DRUGS | LIPOSOME TECHNOLOGY, INC. (US) | 1990-06-28 | — | — | WO | claimed |
| US-4780455-A | PHOSPHOLIPIDS OR STEARINS WITH CHOLESTEROL SULFATE OR SODIUM CHOLESTEROL SULFATE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 1988-10-25 | — | — | US | claimed |