Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Cholesterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OSBP | P22059 | 6/20 | 0.89 |
| ▸ | RORC | P51449 | 5/20 | 0.89 |
| ▸ | OSBP2 | Q969R2 | 3/20 | 0.89 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.89 |
| ▸ | USP2 | O75604 | 1/20 | 0.89 |
| ▸ | LMNA | P02545 | 1/20 | 0.89 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.89 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.76 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.76 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.75 |
| ▸ | CRYAB | P02511 | 1/20 | 0.73 |
| ▸ | HMGCR | P04035 | 1/20 | 0.73 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.73 |
| ▸ | ITGAV | P06756 | 1/20 | 0.73 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.73 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.73 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.72 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.71 |
| ▸ | DHCR24 | Q15392 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cholesterol SCHEMBL27237461 | 1.00 | OSBP (0.89) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL1965451 | 0.99 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL27579873 | 0.99 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL9458834 | 0.99 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL192030 | 0.99 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL29094044 | 0.99 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL26086800 | 0.99 | OSBP (0.91) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL159924 | 0.98 | OSBP (0.89) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL21879229 | 0.98 | OSBP (0.89) | OSBPRORCOSBP2CYP46A1USP2 | |
| Cholesterol SCHEMBL3792432 | 0.98 | OSBP (0.89) | OSBPRORCOSBP2CYP46A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101797264-B | Amphotericin B lipid complex for injection and preparation method thereof | REGENEX CORP CO LTD | 2012-05-30 | — | — | CN | claimed |
| CN-101797264-A | Amphotericin B lipid complex for injection and preparation method thereof | REGENEX CORP CO LTD | 2010-08-11 | — | — | CN | claimed |
| CN-101579310-A | Decataxel self-microemulsifying composition and preparation method thereof | UNIV SHENYANG PHARMACEUTICAL (CN) | 2009-11-18 | — | — | CN | claimed |
| CN-100496609-C | Stable liposome composition | AILISI MEDICINE TECH CO LTD (CN) | 2009-06-10 | — | — | CN | claimed |
| CN-101439033-A | Polyenic taxusol lipid complexes and micelle composition thereof for injection | SHENYANG WOSEN PHARMACEUTICAL (CN) | 2009-05-27 | — | — | CN | claimed |
| CN-101439037-A | Alprostadil lipid complexes and micelle composition thereof for injection | SHENYANG WOSEN PHARMACEUTICAL (CN) | 2009-05-27 | — | — | CN | claimed |
| CN-101439034-A | Tanshinone IIA lipid complexes and micelle composition thereof for injection | SHENYANG WOSEN PHARMACEUTICAL (CN) | 2009-05-27 | — | — | CN | claimed |
| CN-101439032-A | Paclitaxel lipid complexes and micelle composition thereof for injection | SHENYANG WOSEN PHARMACEUTICAL (CN) | 2009-05-27 | — | — | CN | claimed |
| CN-101002733-A | Stable elaioplast composition | AILISI MEDICINE TECH CO LTD SH (CN) | 2007-07-25 | — | — | CN | claimed |
| EP-1773366-A2 | DISSOLVABLE FILM COMPOSITION | E-L Management Corp. (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006009987-A2 | DISSOLVABLE FILM COMPOSITION | E-L MANAGEMENT CORP. (US) | 2006-01-26 | — | — | WO | claimed |
| US-20060002987-A1 | Dissolvable film composition | BEVACQUA ANDREW J | 2006-01-05 | — | — | US | claimed |
| EP-0265467-B1 | METHOD FOR FACILITATING THE FORMATION OF LIPIDIC SPHERULES DISPERSED IN AN AQUEOUS PHASE AND FOR IMPROVING THEIR STABILITY AND THEIR ENCAPSULATION RATIO, AND CORRESPONDING DISPERSIONS | L'OREAL (FR) | 1990-07-04 | — | — | EP | claimed |
| US-20250382402-A1 | LIPID NANODISCS SOLUBILIZED THROUGH POLY(ACRYLIC ACID-CO-STYRENE) COPOLYMERS | UNIV LELAND STANFORD JUNIOR (US) | 2025-12-18 | — | — | US | disclosed |
| EP-4629965-A1 | COSMETICAL AND PHARMACEUTICAL COMPOSITIONS CONTAINING BACILLUS STRAINS OR FERMENTATION BROTHS THEREOF | Evonik Operations GmbH (DE) | 2025-10-15 | — | — | EP | disclosed |
| US-12378337-B2 | Lipid nanodiscs solubilized through poly(acrylic acid-co-styrene) copolymers | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2025-08-05 | — | — | US | disclosed |
| WO-2004052279-A2 | METHOD OF CURL RETENTION IN HAIR AND LASHES | E-L MANAGEMENT CORP. (US) | 2004-06-24 | — | — | WO | disclosed |
| EP-1420743-A2 | CHOLESTEROL SULFATE AND AMINO SUGAR COMPOSITIONS FOR ENHANCEMENT OF STRATUM CORNEUM FUNCTION | Color Access, Inc. (US) | 2004-05-26 | — | — | EP | disclosed |
| US-20020142013-A1 | Cholesterol sulfate and amino sugar compositions for enhancement of stratum corneum function | COLOR ACCESS, INC. | 2002-10-03 | — | — | US | disclosed |
| WO-2002060381-A2 | CHOLESTEROL SULFATE AND AMINO SUGAR COMPOSITIONS FOR ENHANCEMENT OF STRATUM CORNEUM FUNCTION | COLOR ACCESS, INC. (US) | 2002-08-08 | — | — | WO | disclosed |