Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.41 |
| ▸ | GBA1 | P04062 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22688335 | 0.94 | PAOX (0.33) | PAOXACHEALDH1A1 | |
| SCHEMBL20375297 | 0.87 | TLR4 (0.32) | ALDH1A1 | |
| SCHEMBL27316261 | 0.82 | ALDH1A1 (0.34) | GBA1MAPK1TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL27309028 | 0.82 | ALDH1A1 (0.34) | GBA1MAPK1TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL27320149 | 0.77 | MTNR1A (0.34) | MAPK1TSHRALDH1A1 | |
| SCHEMBL19203502 | 0.75 | KDM4E (0.30) | MAPK1 | |
| SCHEMBL20763500 | 0.75 | EPHX2 (0.35) | MAPK1TSHRLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL19981680 | 0.75 | PAOX (0.34) | PAOXACHE | |
| SCHEMBL24686276 | 0.75 | GAA (0.44) | LMNACYP1A2SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL20051792 | 0.74 | CAPN1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023000131-A1 | ANTIBODY DRUG CONJUGATE LOADED WITH DOUBLE TOXINS AND APPLICATION THEREOF | 烟台迈百瑞国际生物医药股份有限公司 | 2023-01-26 | — | — | WO | disclosed |
| WO-2017132173-A1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | REGENERON PHARMACEUTICALS, INC. (US) | 2017-08-03 | — | — | WO | disclosed |