Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GALR2 | O43603 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20915018 | 0.80 | BRD4 (0.40) | LMNAPOLBGALR2ALDH1A1TDP1 | |
| SCHEMBL2985420 | 0.75 | TSHR (0.43) | MEN1KMT2ATSHRCYP3A4KDM4E | |
| SCHEMBL27831883 | 0.73 | TSHR (0.47) | MEN1KMT2ATSHRCYP3A4LMNA | |
| SCHEMBL10864942 | 0.73 | TSHR (0.42) | MEN1KMT2ATSHRCYP3A4KDM4E | |
| SCHEMBL11286572 | 0.72 | AXL (0.39) | KDM4EBRD4 | |
| SCHEMBL1746108 | 0.71 | TSHR (0.43) | MEN1KMT2ATSHRCYP3A4LMNA | |
| SCHEMBL19820203 | 0.70 | KLKB1 (0.43) | KDM4E | |
| SCHEMBL858396 | 0.70 | RIPK1 (0.51) | BRD4 | |
| SCHEMBL25613107 | 0.70 | SMN1; SMN2 (0.39) | MEN1NPC1RAB9AKMT2ALMNA | |
| SCHEMBL4242878 | 0.69 | ALDH1A1 (0.44) | LMNAALDH1A1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017132474-A1 | BCL-2 INHIBITORS | NEWAVE PHARMACEUTICAL INC. (US) | 2017-08-03 | — | — | WO | disclosed |