Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3316587 | 0.74 | CA1 (0.55) | GAAPOLBPKMGRM4HTT | |
| SCHEMBL6582500 | 0.73 | GAA (0.54) | GAAPOLBPKMGRM4ALDH1A1 | |
| SCHEMBL28510674 | 0.70 | HTT (0.38) | GAAHTTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL9117283 | 0.70 | HDAC3 (0.40) | GAAHTTSMN1; SMN2ATMHSD17B10 | |
| SCHEMBL4455631 | 0.69 | HTT (0.58) | PKMHTTLMNAALDH1A1L3MBTL1 | |
| SCHEMBL1200665 | 0.68 | TRPV4 (0.53) | GAALMNAALDH1A1SMN1; SMN2ATM | |
| SCHEMBL12186139 | 0.68 | L3MBTL1 (0.44) | GRM4ALDH1A1L3MBTL1 | |
| SCHEMBL29907222 | 0.68 | TRPV4 (0.53) | GAALMNAALDH1A1SMN1; SMN2ATM | |
| SCHEMBL24254286 | 0.67 | GAA (0.54) | GAAPOLBPKMMAPT | |
| SCHEMBL9911399 | 0.67 | KMT2A (0.46) | GAALMNAALDH1A1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017133664-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT， AMELIORATION OR PREVENTION OF INFLUENZA | SAVIRA PHARMACEUTICALS GMBH (AT) | 2017-08-10 | — | — | WO | disclosed |