Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10245160 | 0.90 | TSHR (0.49) | L3MBTL1KDM4ESMN1; SMN2MMP2NPC1 | |
| SCHEMBL13263618 | 0.88 | NAAA (0.49) | LMNAL3MBTL1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL1763316 | 0.87 | CCNE2 (0.39) | LMNARIPK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL10780680 | 0.87 | NAAA (0.51) | LMNAL3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL22372109 | 0.84 | KDM4E (0.48) | KDM4EKMT2ASMN1; SMN2TP53 | |
| SCHEMBL30162712 | 0.84 | ACR (0.40) | POLBL3MBTL1KDM4EKMT2ARAB9A | |
| SCHEMBL9999597 | 0.82 | MAOB (0.45) | LMNAKDM4EKMT2A | |
| SCHEMBL31469580 | 0.81 | HTT (0.49) | LMNAGAAKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL27921654 | 0.81 | LMNA (0.41) | LMNAL3MBTL1KDM4EKMT2ANPSR1 | |
| SCHEMBL19852903 | 0.79 | MAPK8 (0.42) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2326181-A1 | ANTIFUNGAL AGENTS | Merck Sharp & Dohme Corp. (US) | 2011-06-01 | — | — | EP | disclosed |
| WO-2010019204-A1 | ANTIFUNGAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2010-02-18 | — | — | WO | disclosed |
| EP-0126326-B1 | PROCESS FOR PREPARING 1,2,4-TRIAZOLE-3-CARBOXAMIDES | UBE INDUSTRIES, LTD. (JP) | 1987-08-05 | — | — | EP | disclosed |
| US-4578479-A | Process for preparing 1,2,4-triazole-3-carboxamides | UBE INDUSTRIES, LTD. (JP) | 1986-03-25 | — | — | US | disclosed |
| EP-0126326-A1 | Process for preparing 1,2,4-triazole-3-carboxamides | UBE INDUSTRIES, LTD. (JP) | 1984-11-28 | — | — | EP | disclosed |