Sugi Predict

Sugi Predict / Compounds / SCHEMBL1920580

SCHEMBL1920580

SCHEMBL1920580

COc1ccc(C=CC(=O)O)c(F)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MIF P14174 1/20 0.61
▸ CYP1A1 P04798 1/20 0.58
▸ CYP1A2 P05177 1/20 0.58
▸ CYP1B1 Q16678 1/20 0.58
▸ THRB P10828 1/20 0.56
▸ ATM Q13315 1/20 0.56
▸ CA12 O43570 4/20 0.55
▸ CA9 Q16790 4/20 0.55
▸ CA1 P00915 1/20 0.55
▸ CA2 P00918 1/20 0.55
▸ MAPT P10636 3/20 0.54
▸ ALDH1A1 P00352 2/20 0.54
▸ MEN1 O00255 1/20 0.54
▸ KMT2A Q03164 1/20 0.54
▸ GAA P10253 1/20 0.52
▸ MAOB P27338 1/20 0.51
▸ NPC1 O15118 1/20 0.50
▸ RAB9A P51151 1/20 0.50
▸ SMN1; SMN2 Q16637 1/20 0.50
▸ JUN P05412 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15239140 1.00 MIF (0.61) MIFCYP1A1CYP1A2CYP1B1THRB
SCHEMBL1920579 1.00 MIF (0.61) MIFCYP1A1CYP1A2CYP1B1THRB
SCHEMBL30380928 1.00 MIF (0.61) MIFCYP1A1CYP1A2CYP1B1THRB
SCHEMBL2943901 0.87 ATM (0.56) MIFTHRBATMMAPTALDH1A1
SCHEMBL2943902 0.87 ATM (0.56) MIFTHRBATMMAPTALDH1A1
SCHEMBL29090933 0.87 CYP1A1 (0.58) CYP1A1CYP1A2CYP1B1CA12CA9
SCHEMBL19972316 0.86 CA12 (0.57) CYP1A1CYP1A2CYP1B1CA12CA9
SCHEMBL14272842 0.86 CA12 (0.57) CYP1A1CYP1A2CYP1B1CA12CA9
SCHEMBL22398305 0.86 CA12 (0.57) CYP1A1CYP1A2CYP1B1CA12CA9
SCHEMBL30632936 0.86 CA12 (0.57) CYP1A1CYP1A2CYP1B1CA12CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115321908-A High-performance concrete based on high-quality machine-made sand and preparation method thereof 河南金诺混凝土有限公司 2022-11-11 — — CN claimed
CN-116768792-B Cinnamamide-hydroxypyridone derivative, and preparation method and application thereof 浙江工业大学 2024-10-18 — — CN disclosed
CN-116768792-A Cinnamamide-hydroxypyridone derivative, and preparation method and application thereof 浙江工业大学 2023-09-19 — — CN disclosed
CN-115321908-B High-performance concrete based on high-quality machine-made sand and preparation method thereof 河南金诺混凝土有限公司 2023-05-16 — — CN disclosed
CN-115321908-A High-performance concrete based on high-quality machine-made sand and preparation method thereof 河南金诺混凝土有限公司 2022-11-11 — — CN disclosed
EP-2595952-B1 AGONISTS OF GPR40 CONNEXIOS LIFE SCIENCES PVT LTD (IN) 2020-11-18 — — EP disclosed
EP-3632899-A1 ARYL SUBSTITUTED CARBOXAMIDE DERIVATIVES AS CALCIUM OR SODIUM CHANNEL BLOCKERS RaQualia Pharma Inc. (JP) 2020-04-08 — — EP disclosed
EP-2435407-B1 ARYL SUBSTITUTED CARBOXAMIDE DERIVATIVES AS CALCIUM OR SODIUM CHANNEL BLOCKERS RAQUALIA PHARMA INC (JP) 2019-12-25 — — EP disclosed
US-9522140-B2 Aryl substituted carboxamide derivatives as calcium or sodium channel blockers RAQUALIA PHARMA INC. (JP) 2016-12-20 — — US disclosed
US-9278915-B2 Agonists of GPR40 CONNEXIOS LIFE SCIENCES PVT LTD (IN) 2016-03-08 — — US disclosed
US-7517910-B2 Alkoxyphenylpropanoic acid derivatives TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-04-14 — — US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 — — US disclosed
US-7456218-B2 3-(4-benzyloxyphenyl) propanoic acid derivatives TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-11-25 — — US disclosed
US-20070213364-A1 Alkoxyphenylpropanoic Acid Derivatives TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-09-13 — — US disclosed
US-20070149608-A1 3-(4-Benzyloxyphenyl) propanoic acid derivatives TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-06-28 — — US disclosed
EP-1731505-A1 ALKOXYPHENYLPROPANOIC ACID DERIVATIVES Takeda Pharmaceutical Company Limited (JP) 2006-12-13 — — EP disclosed
EP-1698624-A1 PHENYLPROPANOIC ACID DERIVATIVES Takeda Pharmaceutical Company Limited (JP) 2006-09-06 — — EP disclosed
EP-1697339-A1 3-(4-BENZYLOXYPHENYL)PROPANOIC ACID DERIVATIVES Takeda Pharmaceutical Company Limited (JP) 2006-09-06 — — EP disclosed
EP-1559422-A1 RECEPTOR FUNCTION CONTROLLING AGENT Takeda Pharmaceutical Company Limited (JP) 2005-08-03 — — EP disclosed
WO-2005063729-A1 3-(4-BENZYLOXYPHENYL)PROPANOIC ACID DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2005-07-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070149608-A1 3-(4-Benzyloxyphenyl) propanoic acid derivatives GPR119, GPR55, GLP1R MIF 1536/4885CYP1A1 1348/4885CYP1A2 2828/4885
US-20070213364-A1 Alkoxyphenylpropanoic Acid Derivatives GPR119, FFAR1, GPR55 MIF 1432/4885CYP1A1 1486/4885CYP1A2 2496/4885
US-20090012093-A1 Receptor Function Regulator GPR119, GIPR, INSR MIF 1677/4885CYP1A1 3585/4885CYP1A2 4431/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.