Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.51 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.50 |
| ▸ | CCR8 | P51685 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19206094 | 0.93 | ALDH1A1 (0.61) | ALDH1A1KDM4ETDP1HPGDHTT | |
| SCHEMBL19206092 | 0.88 | ALDH1A1 (0.63) | ALDH1A1KDM4ETDP1HPGDHTT | |
| SCHEMBL6499571 | 0.84 | ALDH1A1 (0.75) | ALDH1A1KDM4ETDP1HPGDHTT | |
| SCHEMBL19206088 | 0.84 | ALDH1A1 (0.58) | ALDH1A1KDM4ETDP1HPGDHTT | |
| SCHEMBL19206069 | 0.84 | SIGMAR1 (0.70) | ALDH1A1KDM4ETDP1HPGDHTT | |
| SCHEMBL6496864 | 0.83 | ALDH1A1 (0.73) | ALDH1A1KDM4ETDP1HPGDHTT | |
| SCHEMBL19206085 | 0.82 | SIGMAR1 (0.64) | ALDH1A1KDM4ETDP1HPGDHTT | |
| SCHEMBL3763705 | 0.81 | ALDH1A1 (0.57) | ALDH1A1KDM4ETDP1HPGDHTT | |
| SCHEMBL19206096 | 0.81 | ALDH1A1 (0.71) | ALDH1A1KDM4ETDP1HPGDHTT | |
| SCHEMBL3763709 | 0.80 | ALDH1A1 (0.57) | ALDH1A1KDM4ETDP1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10377745-B2 | Heterocyclic compounds as NaV channel inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2019-08-13 | — | — | US | disclosed |
| US-20170233377-A1 | HETEROCYCLIC COMPOUNDS AS NAV CHANNEL INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170233377-A1 | HETEROCYCLIC COMPOUNDS AS NAV CHANNEL INHIBITORS AND USES THEREOF | CACNA1B, CACNG6, SCN5A | ALDH1A1 3556/4885KDM4E 2066/4885TDP1 2604/4885 |
| US-10377745-B2 | Heterocyclic compounds as NaV channel inhibitors and uses thereof | CACNA1B, CACNG6, SCN5A | ALDH1A1 3556/4885KDM4E 2066/4885TDP1 2604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.