Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6233873 | 0.70 | ALDH1A1 (0.34) | — | |
| SCHEMBL3919440 | 0.70 | ITGB3 (0.35) | — | |
| Hydrochloric Acid SCHEMBL7013829 | 0.69 | ALDH1A1 (0.33) | — | |
| SCHEMBL460791 | 0.69 | ITGB3 (0.30) | — | |
| SCHEMBL3748192 | 0.63 | — | — | |
| SCHEMBL16339203 | 0.60 | PKM (0.48) | MAP3K14 | |
| SCHEMBL16339205 | 0.60 | PKM (0.48) | MAP3K14 | |
| SCHEMBL16339206 | 0.60 | PKM (0.48) | MAP3K14 | |
| SCHEMBL5894307 | 0.60 | — | — | |
| SCHEMBL3313402 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414239-A2 | INHIBITORS OF RECEPTOR-INTERACTING PROTEIN KINASE 1 | Denali Therapeutics Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |