Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 8/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21496628 | 0.80 | RIPK1 (0.62) | RIPK1NPC1 | |
| SCHEMBL21496629 | 0.80 | RIPK1 (0.62) | RIPK1NPC1 | |
| SCHEMBL29595719 | 0.79 | EPHX2 (0.42) | RIPK1NPC1HPGDTSHRHTT | |
| SCHEMBL18475831 | 0.72 | LTA4H (0.36) | RIPK1MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL22509079 | 0.72 | LTA4H (0.37) | RIPK1MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL19859198 | 0.71 | RIPK1 (0.41) | RIPK1MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL28148475 | 0.68 | TP53 (0.57) | P2RX7MAPK1 | |
| SCHEMBL19207591 | 0.66 | GAA (0.54) | RIPK1 | |
| SCHEMBL29595441 | 0.66 | GAA (0.54) | RIPK1 | |
| SCHEMBL19207593 | 0.66 | GAA (0.54) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414239-A2 | INHIBITORS OF RECEPTOR-INTERACTING PROTEIN KINASE 1 | Denali Therapeutics Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |