Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21496629 | 1.00 | RIPK1 (0.62) | RIPK1NPC1 | |
| SCHEMBL19207593 | 0.82 | GAA (0.54) | RIPK1 | |
| SCHEMBL29595441 | 0.82 | GAA (0.54) | RIPK1 | |
| SCHEMBL19207591 | 0.82 | GAA (0.54) | RIPK1 | |
| SCHEMBL19207981 | 0.80 | RIPK1 (0.45) | RIPK1NPC1 | |
| SCHEMBL15565126 | 0.80 | RIPK1 (0.63) | RIPK1 | |
| SCHEMBL19207856 | 0.80 | RIPK1 (0.63) | RIPK1 | |
| SCHEMBL5312946 | 0.78 | PYGL (0.42) | RIPK1 | |
| SCHEMBL19207987 | 0.78 | RIPK1 (1.00) | RIPK1NPC1 | |
| SCHEMBL19207989 | 0.78 | RIPK1 (1.00) | RIPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3781571-A1 | N-[4-OXO-2,3-DIHYDRO-1,5-BENZOXAZEPIN-3-YL]-5,6-DIHYDRO-4H-PYRROLO[1,2-B]PYRAZOL E-2-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS RIP1 KINASE INHIBITORS FOR TREATING E.G. IRRITABLE BOWEL SYNDROME (IBS) | F. Hoffmann-La Roche AG (CH) | 2021-02-24 | — | — | EP | disclosed |
| WO-2019204537-A1 | N-[4-OXO-2,3-DIHYDRO-1,5-BENZOXAZEPIN-3-YL]-5,6-DIHYDRO-4H-PYRROLO[1,2-B]PYRAZOL E-2-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS RIP1 KINASE INHIBITORS FOR TREATING E.G. IRRITABLE BOWEL SYNDROME (IBS) | GENENTECH, INC. (US) | 2019-10-24 | — | — | WO | disclosed |