Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 19/20 | 1.00 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19207987 | 1.00 | RIPK1 (1.00) | RIPK1NPC1CYP1A2CYP2C9RAB9A | |
| SCHEMBL19228600 | 0.82 | RIPK1 (0.70) | RIPK1 | |
| SCHEMBL22509050 | 0.81 | RIPK1 (0.69) | RIPK1NPC1CYP1A2CYP2C9RAB9A | |
| SCHEMBL19207810 | 0.81 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL19207806 | 0.81 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL19228491 | 0.80 | RIPK1 (0.69) | RIPK1 | |
| SCHEMBL21496628 | 0.78 | RIPK1 (0.62) | RIPK1NPC1 | |
| SCHEMBL21496629 | 0.78 | RIPK1 (0.62) | RIPK1NPC1 | |
| SCHEMBL19207725 | 0.77 | RIPK1 (1.00) | RIPK1CYP2C9 | |
| SCHEMBL19207726 | 0.77 | RIPK1 (1.00) | RIPK1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414239-A2 | INHIBITORS OF RECEPTOR-INTERACTING PROTEIN KINASE 1 | Denali Therapeutics Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |