Lurtotecan

Lurtotecan

SCHEMBL19208

CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2c-1nc1cc3c(cc1c2CN1CCN(C)CC1)OCCO3

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TOP1 P11387 19/20 1.00
SLC2A1 P11166 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lurtotecan SCHEMBL13992 1.00 TOP1 (1.00) TOP1SLC2A1
Lurtotecan SCHEMBL29774186 1.00 TOP1 (1.00) TOP1SLC2A1
Lurtotecan SCHEMBL1649335 0.99 TOP1 (0.98) TOP1SLC2A1
Lurtotecan SCHEMBL29379042 0.99 TOP1 (0.98) TOP1SLC2A1
Lurtotecan SCHEMBL1649336 0.98 TOP1 (0.97) TOP1SLC2A1
SCHEMBL31312371 0.95 TOP1 (1.00) TOP1SLC2A1
SCHEMBL21410041 0.95 TOP1 (1.00) TOP1SLC2A1
SCHEMBL21450469 0.95 TOP1 (1.00) TOP1SLC2A1
SCHEMBL15150090 0.93 TOP1 (0.87) TOP1SLC2A1
SCHEMBL17057475 0.92 TOP1 (0.86) TOP1SLC2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 22729 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144882-A1 ANTI-NECTIN-4 ANTIBODY DRUG CONJUGATE AND USE THEREOF BIO-THERA SOLUTIONS, LTD. (CN) 2026-05-28 US claimed
US-20260137796-A1 PHARMACEUTICAL COMBINATIONS FOR SUBCUTANEOUS ADMINISTRATION AND USE THEREOF SHANGHAI BAO PHARMACEUTICALS CO., LTD. (CN) 2026-05-21 US claimed
EP-4743122-A1 THERAPEUTIC SEALANTS BASED UPON DRUG CONJUGATES The Johns Hopkins University (US) 2026-05-20 EP claimed
EP-4739310-A1 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) INHIBITOR COMBINATIONS AND USES THEREOF Insilico Medicine IP Limited (HK) 2026-05-13 EP claimed
EP-4740956-A1 PHARMACEUTICAL COMBINATION FOR SUBCUTANEOUS ADMINISTRATION AND USE THEREOF Shanghai Bao Pharmaceuticals Co., Ltd. (CN) 2026-05-13 EP claimed
US-20260116861-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-04-30 US claimed
WO-2026090139-A1 ANTI-LY6K ANTIBODY-DRUG CONJUGATES AND METHODS OF USE NORMUNITY, INC. (US) 2026-04-30 WO claimed
EP-4732850-A1 ANTIBODY-DRUG CONJUGATES AND THEIR USES Antelope Therapeutics SAS (FR) 2026-04-29 EP claimed
US-20260091119-A1 ISOLATED TARGETED DELIVERY SYSTEM FOR THE TREATMENT OF GLIOMA CELLIS AG (CH) 2026-04-02 US claimed
EP-4687999-A1 TROP2 CONJUGATED BIOLOGICAL MOLECULES, PHARMACEUTICAL COMPOSITIONS AND METHODS OBI Pharma, Inc. (TW) 2026-02-11 EP claimed
EP-1267939-A2 POLYGLUTAMIC ACID-CAMPTOTHECIN CONJUGATES AND METHODS OF PREPARATION CELL THERAPEUTICS, INC. (US) 2003-01-02 EP claimed
US-20020183243-A1 Polyglutamic acid-camptothecin conjugates and methods of preparation CELL THERAPEUTICS, INC. 2002-12-05 US claimed
WO-2002085459-A2 ANTIANGIOGENIC COMBINATION THERAPY FOR THE TREATMENT OF CANCER PHARMACIA CORPORATION (US) 2002-10-31 WO claimed
US-20020103141-A1 Antiangiogenic combination therapy for the treatment of cancer PHARMACIA CORPORATION 2002-08-01 US claimed
WO-2002053138-A2 TREATMENT FOR INHIBITING NEOPLASTIC LESIONS USING INCENSOLE AND/OR FURANOGERMACRENS SHANAHAN-PRENDERGAST ELISABETH (IE) 2002-07-11 WO claimed
US-20020077290-A1 Polyglutamic acid-camptothecin conjugates and methods of preparation CELL THERAPEUTICS, INC. 2002-06-20 US claimed
EP-1210354-A1 PRODRUGS FOR LIVER SPECIFIC DRUG DELIVERY Metabasis Therapeutics, Inc. (US) 2002-06-05 EP claimed
US-20020016285-A1 Polyglutamic acid-camptothecin conjugates and methods of preparation CELL THERAPEUTICS, INC. 2002-02-07 US claimed
WO-2001070275-A2 POLYGLUTAMIC ACID-CAMPTOTHECIN CONJUGATES AND METHODS OF PREPARATION CELL THERAPEUTICS, INC. (US) 2001-09-27 WO claimed
WO-2001018013-A1 PRODRUGS FOR LIVER SPECIFIC DRUG DELIVERY METABASIS THERAPEUTICS, INC. (US) 2001-03-15 WO claimed