Lurtotecan

Lurtotecan

SCHEMBL29774186

CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2c-1nc1cc3c(cc1c2CN1CCN(C)CC1)OCCO3

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TOP1 P11387 19/20 1.00
SLC2A1 P11166 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lurtotecan SCHEMBL13992 1.00 TOP1 (1.00) TOP1SLC2A1
Lurtotecan SCHEMBL19208 1.00 TOP1 (1.00) TOP1SLC2A1
Lurtotecan SCHEMBL1649335 0.99 TOP1 (0.98) TOP1SLC2A1
Lurtotecan SCHEMBL29379042 0.99 TOP1 (0.98) TOP1SLC2A1
Lurtotecan SCHEMBL1649336 0.98 TOP1 (0.97) TOP1SLC2A1
SCHEMBL31312371 0.95 TOP1 (1.00) TOP1SLC2A1
SCHEMBL21410041 0.95 TOP1 (1.00) TOP1SLC2A1
SCHEMBL21450469 0.95 TOP1 (1.00) TOP1SLC2A1
SCHEMBL15150090 0.93 TOP1 (0.87) TOP1SLC2A1
SCHEMBL17057475 0.92 TOP1 (0.86) TOP1SLC2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4716554-A1 PD-L1 AND TROP-2 TARGETING CONJUGATES COMPRISING EFFECTOR MOLECULES AND USES THEREOF Allygen Group (KY) 2026-04-01 EP disclosed
WO-2024240162-A9 PD-L1 AND TROP-2 TARGETING CONJUGATES COMPRISING EFFECTOR MOLECULES AND USES THEREOF SHANGHAI ALLYGEN BIOLOGICS CO., LTD. (CN) 2025-04-10 WO disclosed
WO-2024240162-A1 PD-L1 AND TROP-2 TARGETING CONJUGATES COMPRISING EFFECTOR MOLECULES AND USES THEREOF SHANGHAI ALLYGEN BIOLOGICS CO., LTD. (CN) 2024-11-28 WO disclosed
US-20240299576-A1 TARGETING CONJUGATES COMPRISING EFFECTOR MOLECULES AND USES THEREOF ALLYGEN GROUP (KY) 2024-09-12 US disclosed
US-20240189442-A1 TARGETING CONJUGATES WITH THERAPEUTIC AGENTS AND OLIGONUCLEOTIDES AND USES THEREOF ALLYGEN GROUP (KY) 2024-06-13 US disclosed
EP-4297798-A1 TARGETING CONJUGATES COMPRISING EFFECTOR MOLECULES AND USES THEREOF Allygen Group (KY) 2024-01-03 EP disclosed
EP-4297791-A1 TARGETING CONJUGATES WITH THERAPEUTIC AGENTS AND OLIGONUCLEOTIDES AND USES THEREOF Allygen Group (KY) 2024-01-03 EP disclosed
US-20230190690-A1 THERAPEUTIC AND/OR PREVENTIVE AGENT FOR CORONAVIRUS DISEASE 2019 (COVID-19) NEOPHARMA JAPAN CO., LTD. (JP) 2023-06-22 US disclosed
CN-115768415-A Novel therapeutic and/or prophylactic agent for coronavirus infection (COVID-19) 日本纽翱医药股份有限公司 2023-03-07 CN disclosed
EP-4140479-A1 THERAPEUTIC AND/OR PREVENTIVE AGENT FOR CORONAVIRUS DISEASE 2019 (COVID-19) Neopharma Japan Co., Ltd. (JP) 2023-03-01 EP disclosed
US-20220395497-A1 Cancer Treatment Using Camptothecin Derivatives VIVACITAS ONCOLOGY, INC. (US) 2022-12-15 US disclosed
US-11467158-B2 BRCA1 mutations as predictive markers for topoisomerase inhibitions BOSTON MEDICAL CENTER CORPORATION (US) 2022-10-11 US disclosed
WO-2022205316-A1 TARGETING CONJUGATES COMPRISING EFFECTOR MOLECULES AND USES THEREOF SHANGHAI ALLYGEN BIOLOGICS CO., LTD. (CN) 2022-10-06 WO disclosed
US-11433136-B2 Polyacetal polymers, conjugates, particles and uses thereof THE GENERAL HOSPITAL CORPORATION (US) 2022-09-06 US disclosed
WO-2022178754-A1 TARGETING CONJUGATES WITH THERAPEUTIC AGENTS AND OLIGONUCLEOTIDES AND USES THEREOF SHANGHAI ALLYGEN BIOLOGICS CO., LTD. (CN) 2022-09-01 WO disclosed
WO-2022179571-A1 TARGETING CONJUGATES COMPRISING TARGETING MOIETY BINDING FRAGMENTS AND USES THEREOF SHANGHAI ALLYGEN BIOLOGICS CO., LTD. (CN) 2022-09-01 WO disclosed
WO-2022178753-A1 TARGETING CONJUGATES COMPRISING TARGETING MOIETY BINDING FRAGMENTS AND USES THEREOF SHANGHAI ALLYGEN BIOLOGICS CO., LTD. (CN) 2022-09-01 WO disclosed
WO-2022179572-A1 TARGETING CONJUGATES WITH THERAPEUTIC AGENTS AND OLIGONUCLEOTIDES AND USES THEREOF SHANGHAI ALLYGEN BIOLOGICS CO., LTD. (CN) 2022-09-01 WO disclosed
WO-2022178751-A1 TARGETING CONJUGATES COMPRISING EFFECTOR MOLECULES AND USES THEREOF SHANGHAI ALLYGEN BIOLOGICS CO., LTD. (CN) 2022-09-01 WO disclosed
WO-2022179570-A1 TARGETING CONJUGATES COMPRISING EFFECTOR MOLECULES AND USES THEREOF SHANGHAI ALLYGEN BIOLOGICS CO., LTD. (CN) 2022-09-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11433136-B2 Polyacetal polymers, conjugates, particles and uses thereof CD44, FUT6, MSN TOP1 1036/4885SLC2A1 1035/4885
US-20240189442-A1 TARGETING CONJUGATES WITH THERAPEUTIC AGENTS AND OLIGONUCLEOTIDES AND USES THEREOF DCLRE1B, TERF2, PAICS TOP1 97/4885SLC2A1 2983/4885
US-20230190690-A1 THERAPEUTIC AND/OR PREVENTIVE AGENT FOR CORONAVIRUS DISEASE 2019 (COVID-19) ACE, ACE2, IL5 TOP1 4066/4885SLC2A1 1498/4885
US-20240299576-A1 TARGETING CONJUGATES COMPRISING EFFECTOR MOLECULES AND USES THEREOF GZMB, KLK3, CD47 TOP1 2572/4885SLC2A1 4795/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.