Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | CFD | P00746 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19208208 | 0.86 | SSTR4 (0.54) | SSTR4RIPK1RENP2RX7EGFR | |
| SCHEMBL16701484 | 0.81 | RIPK1 (0.48) | SSTR4RIPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL19208297 | 0.80 | SSTR4 (0.39) | SSTR4RIPK1RENEGFRERBB2 | |
| SCHEMBL19208044 | 0.79 | REN (0.39) | SSTR4RENP2RX7HDAC3HDAC1 | |
| SCHEMBL16397127 | 0.72 | RPS6KA1 (0.48) | P2RX7CFDDRD2 | |
| SCHEMBL21257736 | 0.71 | HDAC3 (0.35) | RENEGFRERBB2HDAC3HDAC1 | |
| SCHEMBL14804194 | 0.70 | KMT2A (0.48) | SSTR4HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL19208107 | 0.70 | P2RX7 (0.41) | P2RX7CFDSMN1; SMN2 | |
| SCHEMBL14157466 | 0.70 | CA14 (0.42) | SSTR4HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL19208272 | 0.69 | SSTR4 (0.41) | SSTR4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3411411-A1 | BENZOPYRAZOLE COMPOUNDS AND ANALOGUES THEREOF | Biocryst Pharmaceuticals, Inc. (US) | 2018-12-12 | — | — | EP | disclosed |
| WO-2017136395-A1 | BENZOPYRAZOLE COMPOUNDS AND ANALOGUES THEREOF | BIOCRYST PHARMACEUTICALS, INC. (US) | 2017-08-10 | — | — | WO | disclosed |