Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | Q9HBH1 | 1/20 | 0.38 | |
| ▸ | SSTR3 | P32745 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16599526 | 0.91 | HTR2A (0.54) | HTR2AALDH1A1MAPK1L3MBTL1TGM2 | |
| SCHEMBL15676014 | 0.88 | HTR2A (0.55) | HTR2AALDH1A1MAPK1L3MBTL1HTT | |
| SCHEMBL12477118 | 0.87 | HTR2A (0.58) | HTR2AALDH1A1MAPK1L3MBTL1HTT | |
| SCHEMBL16599524 | 0.85 | HTR2A (0.52) | HTR2AALDH1A1MAPK1L3MBTL1TGM2 | |
| SCHEMBL19209358 | 0.82 | HTR2A (0.55) | HTR2AALDH1A1MAPK1L3MBTL1HTT | |
| SCHEMBL15676464 | 0.81 | HTR2A (0.44) | HTR2AALDH1A1MAPK1L3MBTL1TGM2 | |
| SCHEMBL12476204 | 0.80 | HTR2A (0.45) | HTR2AALDH1A1MAPK1L3MBTL1HTT | |
| SCHEMBL12475924 | 0.80 | HTR2A (0.45) | HTR2AALDH1A1MAPK1L3MBTL1HTT | |
| SCHEMBL18941468 | 0.80 | PDF (0.48) | HTR2AALDH1A1MAPK1L3MBTL1GAA | |
| SCHEMBL18941467 | 0.80 | PDF (0.48) | HTR2AALDH1A1MAPK1L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3411371-A1 | TUBULYSIN ANALOGS AND METHODS FOR THEIR PREPARATION | Pfizer Inc (US) | 2018-12-12 | — | — | EP | disclosed |
| WO-2017134547-A1 | TUBULYSIN ANALOGS AND METHODS FOR THEIR PREPARATION | PFIZER INC. (US) | 2017-08-10 | — | — | WO | disclosed |