Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12476204 | 1.00 | HTR2A (0.45) | HTR2AGAAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL12476207 | 0.87 | ALDH1A1 (0.47) | HTR2AGAAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL12475982 | 0.87 | ALDH1A1 (0.47) | HTR2AGAAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL12476680 | 0.81 | HTR2A (0.45) | HTR2AGAAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL19209361 | 0.80 | HTR2A (0.55) | HTR2AGAAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL15676014 | 0.79 | HTR2A (0.55) | HTR2AGAAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL12476676 | 0.77 | SSTR3 (0.49) | HTR2AGAAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL12477118 | 0.76 | HTR2A (0.58) | HTR2AGAAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL6594172 | 0.73 | HTR2A (0.74) | HTR2AGAAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL16599526 | 0.72 | HTR2A (0.54) | HTR2AGAAALDH1A1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3147367-A1 | SMALL MOLECULE CONJUGATES FOR INTRACELLULAR DELIVERY OF NUCLEIC ACIDS | F. Hoffmann-La Roche AG (CH) | 2017-03-29 | — | — | EP | disclosed |
| EP-2658982-A1 | SMALL MOLECULE CONJUGATES FOR INTRACELLULAR DELIVERY OF BIOLOGICALLY ACTIVE COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-06 | — | — | EP | disclosed |
| WO-2012089602-A1 | SMALL MOLECULE CONJUGATES FOR INTRACELLULAR DELIVERY OF BIOLOGICALLY ACTIVE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-05 | — | — | WO | disclosed |
| WO-2012091010-A1 | BICYCLIC PYRIMIDINE DERIVATIVE | 大日本住友製薬株式会社 (JP) | 2012-07-05 | — | — | WO | disclosed |